Endotracheal Tube Cuff Pressures in Ventilated Patients

There is no accepted standard for the frequency of monitoring endotracheal tube cuff
pressures (ETCP). Investigator plans on comparing two strategies for monitoring ETCP in
mechanically ventilated patients. The two strategies will be the currently employed practice
at Barnes-Jewish Hospital (BJH) which requires ETCP to be assessed immediately after the
endotracheal tube is placed and after any manipulation of the endotracheal tube to include
repositioning, manipulation of the cuff volume, or presence of an audible leak. The alternate
practice will be pre-scheduled as is performed at other hospitals and includes the same
elements as noted in the current practice but also require monitoring ETCP a minimum of every
work shift (every 8 hours or three times per day). The ETCP will be assessed using a standard
manometer. The two practices will be compared by assessing patients assigned to odd and even
beds in the medical ICU (8400 ICU) with alternate methods. Specifically, patients in odd
numbered rooms will have ETCP checked per the current Barnes-Jewish practice and those in
even rooms having the additional checks of ETCP performed immediately following intubation as
well as every shift and when when assessed required by respiratory therapist. It is important
to note that the respiratory therapists performing ETCP assessments are simply performing a
routine 2- 3 minute task (per cuff pressure measurement) while taking care of patients on
mechanical ventilation.

Our hypothesis is that increased monitoring frequency of ETCP will not result in a decrease
in the duration of mechanical ventilation for patients admitted to the medical intensive care
unit (ICU) of BJH or a reduction in ventilator-associated events.

Currently there is no accepted gold standard for the frequency of monitoring ETCP. There are
widely different strategies reported for monitoring ETCP to include continuous monitoring.
The goal of ETCP monitoring is to maintain the ETCP between 20-30 cmH2O in order to minimize
cuff leaks and pressure injury to the tracheal mucosa. It is known that 20 to 30% of the time
the ETCP may deviate above or below this threshold. However, the impact of such deviation on
clinical outcomes is not well described in the medical literature. The two most common
methods for assessing ETCP is the use of a manometer and/or setting a minimal leak, with the
former being the most accepted method. However, the optimal frequency for conducting
manometric monitoring of ETCP is unknown. One recent study suggests that the act of measuring
ETCP frequently in order to achieve a desired pressure level results in the removal of air
from the cuff and can result in under inflation of the cuff. However, a recent animal study
suggests that the material used to manufacture the endotracheal tube cuff may play a more
important role in determining the presence or absence of mucosal injury, with polyurethane
being better than polyvinylchloride. The main problem with these studies is the failure to
assess clinical outcomes at the bedside with the use of various strategies to maintain an
appropriate endotracheal tube cuff seal. A recent survey of intensivists in Queensland
Australia and accompanying systematic literature review made the following conclusions
regarding ETCP monitoring: "Twenty-eight out of twenty-nine respondents reported routinely
monitoring tracheal cuff function, primarily employing cuff pressure measurement (26/28).
Target cuff pressures varied, with 3/26 respondents aiming for 10 to 20 cmH2O, 10/26 for 21
to 25 cmH2O, and 13/26 for 26 to 30 cmH2O. Fifteen out of twenty-nine reported they had no
current guideline or protocol for tracheal cuff management and only 16/29 indicated there was
a dedicated area in the clinical record for reporting cuff intervention. The results
indicated that many ICUs across Queensland routinely measure tracheal cuff function, with
most utilising pressure monitoring devices. Consistent with existing literature, the optimum
cuff pressure remains uncertain. Most, however, considered that this should be a routine part
of ICU care". Thus, the available literature on ETCP and their relationship to clinical
outcomes is lacking.

Inclusion Criteria:

- Mechanically ventilated patients intubated in a medical intensive care unit

Exclusion Criteria:

- Patient requiring prone positioning, lung transplant and neutropenic patients