Biomarkers for Muscle Function and Aging in Chronic HIV Infection

MATCH is a non-randomized observational longitudinal study. We will recruit HIV infected
adults (50 to 65 years old) and demographically matched uninfected control subjects to be
followed for 4 years over the course of a 5 year study. The targeted age range of 50-65 is
chosen to evaluate aging HIV infected individuals at risk for early frailty in the United
States. All subjects will undergo blood draws and physical function assessment, and a subset
will undergo a CT scan of muscle and will have a muscle biopsy taken.

A substudy will be performed on a subgroup of HIV-infected and HIV-uninfected men from the
main cohort to measure daily physical activity by using an activity tracker.

Inclusion Criteria:

Group 1: HIV positive subjects

- HIV positive

- English speaking

- 50-65 years old

- On Antiretroviral therapy and an HIV viral load below 200 copies/ml

- CD4 equal to or greater than 350 cells/mm3

- Postmenopausal (women)

- Lower extremity mobility sufficient to participate in functional assessment.

Group 2: HIV negative subjects Inclusion Criteria for Group 2 subjects

- English speaking

- 50-65 years old

- Negative for HIV (based on an HIV antibody test at Study Visit 1)

- Matched to Group 1 for sex (50% W, 50% M) and age (50 - 65yo)

- Postmenopausal (women)

- Lower extremity mobility sufficient to participate in functional assessment.

Exclusion Criteria:

Exclusion Criteria for Group 1 Subjects

- Acute or serious illness within 60 days prior to entry

- Use of pharmacologic doses of corticosteroids in the past 6 months.

- Use of anabolic therapy in the past 6 months.

- Lower extremity mobility insufficient to participate in functional assessment.

- Current use (last 30 days) of anticoagulants or known bleeding disorder.

Exclusion Criteria for Group 2 subjects

- Acute or serious illness within 60 days prior to entry

- Use of pharmacologic doses of corticosteroids in the past 6 months

- Use of anabolic therapy in the past 6 months

- Lower extremity mobility insufficient to participate in functional assessment

- Current use (last 30 days) of anticoagulants or known bleeding disorder.