Assessment of Duodenal Epithelial Integrity in Celiac Disease With Mucosal Impedance



Status:Enrolling by invitation
Conditions:Endocrine
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 99
Updated:12/21/2018
Start Date:December 2016
End Date:June 2019

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Trial Summary
Trial Overview
Inclusion Criteria
Increased intestinal permeability can represent compromise of the epithelium's integrity and
is thought to be the primary mechanism in patients who develop Celiac Disease (CeD) and
non-celiac gluten sensitivity when gluten peptides cross the barrier and trigger an immune
response. In this study, the investigators propose to use a novel, minimally invasive
technology to detect mucosal damage (i.e. barrier dysfunction) in the duodenal epithelium.
The primary aim of this study is to identify if there is a difference in duodenal mucosal
impedance between CeD and control patients.


Inclusion Criteria:

- scheduled for endoscopy as part of routine care with or without suspected Celiac
Disease based upon at least 1 positive serologic marker of CeD

- consuming gluten at time of endoscopy

Exclusion Criteria:

- Already on a gluten free diet or unwilling to undergo a gluten challenge

- Undergoing upper endoscopy for an urgent indication such as unstable gastrointestinal
bleed or food impaction

- Patients with inflammatory bowel disease

- Patients on blood thinners other than aspirin at time of endoscopy

- Patient unable to give informed consent

- Patient less than 18 years old
We found this trial at
1
site
Vanderbilt University Medical Center Endoscopy Laboratory
Nashville, Tennessee 37232
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mi
from
Nashville, TN
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