Assessment of Colonic Epithelial Integrity With Mucosal Impedance
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS), Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 99 |
| Updated: | 12/23/2018 |
| Start Date: | November 2016 |
| End Date: | June 2019 |
In this study, the investigators propose to use mucosal impedance (MI), a minimally invasive
technology, to detect mucosal damage (i.e. barrier dysfunction) based on mucosal conductivity
changes in the colonic epithelium.
technology, to detect mucosal damage (i.e. barrier dysfunction) based on mucosal conductivity
changes in the colonic epithelium.
The intestinal epithelium functions to separate luminal contents from the interstitium.
Increased intestinal permeability can represent compromise of the epithelium's integrity.
Prior research has demonstrated that defects in intestinal barrier function are associated
with inflammatory bowel disease (IBD) and increased intestinal permeability can be important
in the maintenance of remission in IBD patients. There is currently not a convenient way to
measure colonic epithelial barrier function in real time which could provide clinically
relevant information .
Increased intestinal permeability can represent compromise of the epithelium's integrity.
Prior research has demonstrated that defects in intestinal barrier function are associated
with inflammatory bowel disease (IBD) and increased intestinal permeability can be important
in the maintenance of remission in IBD patients. There is currently not a convenient way to
measure colonic epithelial barrier function in real time which could provide clinically
relevant information .
Inclusion Criteria:
- Men and women over the age of 18 with a diagnosis of IBD (Ulcerative Colitis or
Crohn's Disease)
- Men and women undergoing screening colonoscopy (typical age would be 50 or greater but
there are exceptions)
Exclusion Criteria:
- Age less than 18 years old
- Patients unable to give informed consent
- Patients with history of colonic surgeries
- Patients with history of colonic motility disorder
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