A Clinical Evaluation of the Treatment of Spider Veins on the Ankles

The purpose of this study is to evaluate the real-world effectiveness of the 532 nm KTP and
1064 nm Nd:YAG lasers within the Cutera Excel V system for the treatment of lower extremity
spider veins, specifically on the ankles, within a clinic setting.

Inclusion Criteria:

1. Males or females, 20 to 75 years of age (inclusive).

2. Fitzpatrick Skin Type I - III.

3. Having spider veins on at least 1 ankle measuring 2.0mm or less in diameter, linear or
branching, and red, pink, blue and/or purple in color, as assessed by the
investigator.

4. Having spider veins on the ankle that are appropriate for laser treatment, as assessed
by the investigator.

5. Subject must be able to read, understand and sign the Informed Consent Form.

6. Subject must be willing and able to adhere to the treatment and follow-up schedule and
post-treatment care instructions.

7. Wiling to have limited sun exposure for the duration of the study, including the
follow-up period.

8. Willingness to have digital photographs taken of ankle spider veins and agree to use
of photographs for presentation, educational or marketing purposes.

9. Agree not to undergo any other procedure for the treatment of ankle spider veins
during the study.

Exclusion Criteria:

1. Fitzpatrick Skin Type IV - VI.

2. Pregnant.

3. Having an infection, dermatitis or a rash in the treatment area.

4. Having significant varicosities or perforator veins.

5. History of pigmentary disorders, particularly tendency for hyper- or
hypo-pigmentation.

6. Systemic use of isotretinoin (Accutane®) within 6 months of study participation.

7. Excessively tanned in areas to be treated or unable/unlikely to refrain from tanning
during the study.

8. In the opinion of the investigator, any physical or mental condition which might make
it unsafe for the subject to participate in this study or which requires systemic
therapy that could interfere with this research study.