Dental Malocclusion and Craniofacial Development in OI
| Status: | Recruiting |
|---|---|
| Conditions: | Orthopedic, Dental |
| Therapuetic Areas: | Dental / Maxillofacial Surgery, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 10 - 100 |
| Updated: | 1/25/2018 |
| Start Date: | August 2016 |
| End Date: | July 2025 |
| Contact: | Dianne Dang |
| Email: | diannen@bcm.edu |
| Phone: | 713-798-6694 |
Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily.
Individuals with osteogenesis imperfecta break bones often and may have other problems,
including hearing loss and pain and difficulty getting around. People with moderate to severe
OI may also be diagnosed with dentinogenesis imperfecta (DI). DI is characterized by grey or
brown teeth that may chip and wear down and break easily. People with DI may also have skull
and neck defects. These patients may have severe teeth misalignment resulting in clinically
significant chewing problems. Teeth misalignment in OI is very hard to treat because of the
quality and quantity of bone. The overall goal of this study is to improve dental health to
improve the quality of life of people with OI.
Individuals with osteogenesis imperfecta break bones often and may have other problems,
including hearing loss and pain and difficulty getting around. People with moderate to severe
OI may also be diagnosed with dentinogenesis imperfecta (DI). DI is characterized by grey or
brown teeth that may chip and wear down and break easily. People with DI may also have skull
and neck defects. These patients may have severe teeth misalignment resulting in clinically
significant chewing problems. Teeth misalignment in OI is very hard to treat because of the
quality and quantity of bone. The overall goal of this study is to improve dental health to
improve the quality of life of people with OI.
Investigators will look at dental health in people with OI and will describe teeth
misalignment and head and neck defects in individuals with moderate to severe Osteogenesis
Imperfecta (OI).
Investigators will look at results from the Longitudinal study of OI to complete the study
evaluations. Several x-rays will be performed for this study. Participants will have a 3D
scan of the mouth and a Cone Beam CT scan of the jaw at a baseline visit and at 3 years after
the baseline visit. These study visits can be at the same time as the Longitudinal Study of
OI study visits.
misalignment and head and neck defects in individuals with moderate to severe Osteogenesis
Imperfecta (OI).
Investigators will look at results from the Longitudinal study of OI to complete the study
evaluations. Several x-rays will be performed for this study. Participants will have a 3D
scan of the mouth and a Cone Beam CT scan of the jaw at a baseline visit and at 3 years after
the baseline visit. These study visits can be at the same time as the Longitudinal Study of
OI study visits.
Inclusion Criteria:
- Males and females with Clinical diagnosis of OI other than OI type I
- Individuals 10 years or older
- Participant of the Brittle Bone Disease (BBD) Longitudinal Study (7701)
Exclusion Criteria:
- Individuals who cannot be correctly positioned for valid radiographic analysis (e.g.,
due to severe scoliosis or short neck secondary to basilar invagination)
- Women who are pregnant
We found this trial at
4
sites
535 E 70th St
New York, New York 10021
New York, New York 10021
(212) 606-1000
Principal Investigator: Cathleen Raggio, M.D.
Phone: 212-774-7332
Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery is the nation
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1200 Moursund Street
Houston, Texas 77030
Houston, Texas 77030
(713) 798-4951
Principal Investigator: Reid Sutton, M.D.
Phone: 713-798-6694
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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Los Angeles, California 90095
310-825-4321
Principal Investigator: Deborah Krakow, M.D.
Phone: 310-794-6420
University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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Montreal, Quebec
Principal Investigator: Jean-Marc Retrouvey, D.M.D.
Phone: 514-282-7158
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