PPROM Registry (Preterm Premature Rupture of Membranes)

Detailed Description

Preterm Premature Rupture of Membranes (pProm) is a factor in 40% of preterm births. The
earlier in pregnancy pProm occurs, the greater the potential latency period. Threats to the
pregnancy include placental abruption, umbilical cord prolapse, infection, and insufficient
pulmonary development, and preterm delivery. Management of pProm may include immediate
delivery, induction, or expectant management.

It is still unclear what is considered best practice for the course of treatment in pProm
pregnancies and post- delivery care of pProm babies in Neonatal Intensive Care Units (NICU),
as well as the long term outcomes of pProm survivors. Unfortunately, there are few recent
studies available for review and those that exist often do not reflect the current treatments
or innovations that have taken place, especially in neonatal care. Many of the studies
available focusing on pProm have very small sample sizes, as well as very short follow-up
post-delivery, resulting in a wide range of reported outcomes, especially regarding the
morbidity and mortality associated with pProm.

The pProm registry is the first of its kind and will provide a large cohort of data for
study. The purpose of this registry is to better understand pregnancies and births impacted
by pProm. This includes how pProm is managed in pregnancy and in how pProm neonates are cared
for in the NICU; identifying trends in expectant management, and to detect short term and
long term outcomes of those affected.

Inclusion Criteria:

- Women diagnosed with Preterm Premature Rupture of Membranes (PPROM) prior to 37 weeks
of pregnancy

Exclusion Criteria:

- Those without a clinical diagnosis or confirmation of PPROM in pregnancy

- Diagnosis of PROM beyond 37 weeks of pregnancy