A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Hospital, Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 28 - 75 |
| Updated: | 3/2/2019 |
| Start Date: | December 2016 |
| End Date: | June 2019 |
| Contact: | Caitlyn Katzelnick, MS |
| Email: | ckatzelnick@kesslerfoundation.org |
| Phone: | 973-324-3588 |
The general population is aging, today 12% of the United States population is older than 65
and it is estimated that by 2020 the number of people in the United States older than 65 will
outnumber children younger than 5. As the general population ages, the spinal cord injury
(SCI) population is also aging and it is estimated that 14% is older than 60. Although
persons with SCI are living longer, life expectancy remains below that of the general
population with cardiovascular and cerebrovascular diseases accounting for more than 25% of
all deaths since 1995. Similar to findings in the general population, BP dysregulation may
impact cognitive function, and investigators reported poorer performance on tasks of memory
and attention processing in hypotensive individuals with SCI compared to a normotensive SCI
cohort. Thus, it is imperative that investigators work to minimize the impact of cognitive
deficits on these aspects of life quality in persons with SCI as they age. Therefore the
goals of this study are: Study 1) to compare cardiovascular, cerebrovascular and cognitive
function and fMRI between older individuals with SCI (50-75 years) and older age-matched
controls and Study 2) to determine 3-5 year longitudinal changes in cardiovascular,
cerebrovascular and cognitive function and fMRI in relatively young individuals with SCI
(28-54 years) compared to relatively young age-matched controls.
and it is estimated that by 2020 the number of people in the United States older than 65 will
outnumber children younger than 5. As the general population ages, the spinal cord injury
(SCI) population is also aging and it is estimated that 14% is older than 60. Although
persons with SCI are living longer, life expectancy remains below that of the general
population with cardiovascular and cerebrovascular diseases accounting for more than 25% of
all deaths since 1995. Similar to findings in the general population, BP dysregulation may
impact cognitive function, and investigators reported poorer performance on tasks of memory
and attention processing in hypotensive individuals with SCI compared to a normotensive SCI
cohort. Thus, it is imperative that investigators work to minimize the impact of cognitive
deficits on these aspects of life quality in persons with SCI as they age. Therefore the
goals of this study are: Study 1) to compare cardiovascular, cerebrovascular and cognitive
function and fMRI between older individuals with SCI (50-75 years) and older age-matched
controls and Study 2) to determine 3-5 year longitudinal changes in cardiovascular,
cerebrovascular and cognitive function and fMRI in relatively young individuals with SCI
(28-54 years) compared to relatively young age-matched controls.
All potential subjects will undergo a two-part screening process which consists of an initial
screening via telephone and a detailed, in-person screening. Eligible subjects will be
invited to participate in a 4 hour laboratory visit during which their arterial stiffness,
blood pressure, heart rate, respiration rate and, blood flow to the brain will be monitored
at rest and during a comprehensive series of cognitive tests. For Study 1 (cross-sectional),
40 older (50-75 years) individuals with SCI and 20 age-matched non-SCI controls will be
recruited. For study 2 (longitudinal), 30 individuals (28-54 years) with SCI and 20
age-matched non-SCI will be recruited from previous enrollment in the Impact of Age on
Cardiovascular, Cerebrovascular and Cognitive Health in SCI study to learn the longitudinal
changes in cardiovascular, cerebrovascular and cognitive health.
screening via telephone and a detailed, in-person screening. Eligible subjects will be
invited to participate in a 4 hour laboratory visit during which their arterial stiffness,
blood pressure, heart rate, respiration rate and, blood flow to the brain will be monitored
at rest and during a comprehensive series of cognitive tests. For Study 1 (cross-sectional),
40 older (50-75 years) individuals with SCI and 20 age-matched non-SCI controls will be
recruited. For study 2 (longitudinal), 30 individuals (28-54 years) with SCI and 20
age-matched non-SCI will be recruited from previous enrollment in the Impact of Age on
Cardiovascular, Cerebrovascular and Cognitive Health in SCI study to learn the longitudinal
changes in cardiovascular, cerebrovascular and cognitive health.
Inclusion Criteria:
- Study 1) Between the ages of 50-75 years old
- Study 2) Between the ages of 28-54 years old
- Completed Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health study
- For Both:
- Primary language is English
- Additional Inclusion Criteria: SCI Subjects
- Level of injury between C1-T12;
- Non-ambulatory (wheelchair dependent);
- AIS grade A, B, or C;
- Injury occurred more than 1 year ago.
Exclusion Criteria:
- Acute illness or infection;
- Controlled or uncontrolled hypertension or Diabetes mellitus;
- Documented history of traumatic brain injury;
- Stroke
- Epilepsy or seizure disorders;
- Multiple sclerosis & Parkinson's disease;
- Psychiatric disorders (post-traumatic stress disorder, schizophrenia, bipolar
disorder);
- Alzheimer's disease & dementia
We found this trial at
1
site
West Orange, New Jersey 07052
Principal Investigator: Nancy Chiaravalloti, Ph.D
Phone: 973-324-3581
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