Impact of NMES and HPRO on Recovery After SAH
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Endocrine |
| Therapuetic Areas: | Endocrinology, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/12/2018 |
| Start Date: | December 1, 2017 |
| End Date: | April 30, 2019 |
| Contact: | Neeraj Badjatia, MD MSc |
| Email: | nbadjatia@umm.edu |
| Phone: | 4103284515 |
Impact of Neuromuscular Stimulation and High Protein Nutritional Supplementation on Long-term Recovery After Aneurysmal Subarachnoid Hemorrhage.
The study purpose is to investigate the hypothesis that in adults with SAH, early
neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will
improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls
receiving standard of care interventions for nutrition and mobilization. The investigators
will accomplish this by studying the effects of a high protein (HPRO) nutritional treatment
as well as NMES intervention have upon muscle wasting and motor strength acutely after SAH.
This will be addressed in a prospective trial of SAH patients receiving HRPO with NMES as
compared to age and severity-matched SAH patients undergoing standard of care interventions
for nutrition and mobilization. Additionally, the study will investigate the impact HPRO and
NMES interventions have upon inflammatory cytokines and markers of energy balance. Results of
this study will establish evidence for precision nutrition plus early exercise to mitigate
the catabolic and inflammatory state produced by SAH to improve muscle, metabolic, and health
recovery outcomes.
neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will
improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls
receiving standard of care interventions for nutrition and mobilization. The investigators
will accomplish this by studying the effects of a high protein (HPRO) nutritional treatment
as well as NMES intervention have upon muscle wasting and motor strength acutely after SAH.
This will be addressed in a prospective trial of SAH patients receiving HRPO with NMES as
compared to age and severity-matched SAH patients undergoing standard of care interventions
for nutrition and mobilization. Additionally, the study will investigate the impact HPRO and
NMES interventions have upon inflammatory cytokines and markers of energy balance. Results of
this study will establish evidence for precision nutrition plus early exercise to mitigate
the catabolic and inflammatory state produced by SAH to improve muscle, metabolic, and health
recovery outcomes.
Inclusion Criteria:
1. Aneurysmal subarachnoid hemorrhage (SAH)
2. Aneurysm repair <= 48 hours of ictus
3. Age >18 years old
4. Expected stay in NCCU>72 hours
Exclusion Criteria:
1. SAH from Trauma, rupture of arterovenous malformation, neoplasm, vasculitis or other
secondary causes
2. Unlikely to survive one week post hemorrhage either due to impending brain death or
likely request for withdrawal of care
3. Fraction of inspired oxygen (FiO2)>>60%
4. Positive end - expiratory pressure >7.5 cm H2O
5. Ongoing seizure activity as assessed clinically or by electrographic detection on
continuous electroencephalogram (cEEG)
6. Inability to collect urine for urine urea nitrogen due to inadequate urine output
7. Known pregnancy, malignancy, inflammatory disorder, neuromuscular disorder, or renal
failure
8. Pre Morbid modified Rankin Score >1
9. Evidence of lower extremity hemiparesis or spasticity within 48 hours of injury
10. Prisoner
11. Active military
We found this trial at
1
site
22 S Greene St
Baltimore, Maryland 21201
Baltimore, Maryland 21201
(410) 328-8667
Phone: 410-328-4515
University of Maryland Medical Center Founded in 1823 as the Baltimore Infirmary, the University of...
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