Water and the Gastropressor Response - Tachyphylaxis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 8/12/2018 |
| Start Date: | July 2006 |
| End Date: | December 2019 |
Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)
We are studying the effects of oral water ingestion in patients with orthostatic hypotension.
In this study, we are testing the null hypothesis that the blood pressure increase with oral
water ingestion will not be diminished if a full prior water dose is given a few hours
earlier.
In this study, we are testing the null hypothesis that the blood pressure increase with oral
water ingestion will not be diminished if a full prior water dose is given a few hours
earlier.
We are studying the effects of oral water ingestion in patients with orthostatic hypotension.
This has been termed the Gastropressor Response. In this study, we are testing the null
hypothesis that the blood pressure increase with oral water ingestion will not be diminished
if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will
be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16
oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will
be given to start, with 16 oz again as the second dose.
This has been termed the Gastropressor Response. In this study, we are testing the null
hypothesis that the blood pressure increase with oral water ingestion will not be diminished
if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will
be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16
oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will
be given to start, with 16 oz again as the second dose.
Inclusion Criteria:
- orthostatic hypotension (fall in BP>20/10 mmHg)
- pressor response to water in other studies
- Age 18-80 years
Exclusion Criteria:
- pregnancy
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