Study on the Role of Treatment With Vitamin E on Asthmatic Responses in Allergic Asthmatics
| Status: | Completed |
|---|---|
| Conditions: | Allergy, Asthma |
| Therapuetic Areas: | Otolaryngology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/17/2018 |
| Start Date: | December 2006 |
| End Date: | October 2011 |
Oxidant Stress and Allergic Asthma
Asthma is a common respiratory disease of unknown etiology which currently affects
approximately 7.5 % of the adult population ( ). Asthma is an inflammatory disorder of the
airways. Airway inflammation is evident not only in patients with fatal asthma but also in
mild asthmatics ( ). Oxidant stress, defined as inadequately controlled generation of toxic
reactive oxygen species (ROS) in the cells or tissues is a common feature of inflammation,
and has also been documented in asthma ( , ). However, the current understanding of the
relationship between the inflammation and the oxidant stress in asthmatic airways is poor.
Does oxidant stress contribute to the expression of asthmatic phenotypes independently of
inflammation? If so, could asthmatics benefit from supplementation of antioxidants? These
questions have been nagging us since our laboratory provided credible evidence of oxidant
injury in the airways of allergic asthmatics ( ). The purpose of our study is to more
precisely determine 1/ the pathophysiologic role of oxidative stress, and 2/ usefulness of
antioxidant therapy using vitamin E in allergic asthma.
approximately 7.5 % of the adult population ( ). Asthma is an inflammatory disorder of the
airways. Airway inflammation is evident not only in patients with fatal asthma but also in
mild asthmatics ( ). Oxidant stress, defined as inadequately controlled generation of toxic
reactive oxygen species (ROS) in the cells or tissues is a common feature of inflammation,
and has also been documented in asthma ( , ). However, the current understanding of the
relationship between the inflammation and the oxidant stress in asthmatic airways is poor.
Does oxidant stress contribute to the expression of asthmatic phenotypes independently of
inflammation? If so, could asthmatics benefit from supplementation of antioxidants? These
questions have been nagging us since our laboratory provided credible evidence of oxidant
injury in the airways of allergic asthmatics ( ). The purpose of our study is to more
precisely determine 1/ the pathophysiologic role of oxidative stress, and 2/ usefulness of
antioxidant therapy using vitamin E in allergic asthma.
Inclusion Criteria:
- Normal health status except for allergic asthma
- Physician diagnosis of mild allergic asthma
- Positive allergen skin tests to common aeroallergens
Exclusion Criteria:
- Use of systemic or high doses of inhaled corticosteroids, >840 mcg of inhaled
beclomethasone of its equivalent (as defined in the consensus report (6))
- Past history of severe asthma (as defined in the consensus report (6))
- History of asthma exacerbation within the past month
- History of recent upper respiratory infection within the past month
- Active immunotherapy for allergic diseases
- Significant disease other than allergic asthma and allergic rhinitis, such as coronary
disease, hypertension, renal failure, anemia, immunodeficiency, cancer, diabetes
- Present or remote tobacco smoking
- Use of Over The Counter drugs including acetaminophen and pseudoephedrine, herbs, or
vitamins
- Psychiatric illness that would make adherence to protocol difficult
- Inability to give informed consent
- Nursing or pregnant women
- Woman planning to become pregnant during the study or not using adequate birth control
methods (barrier or hormonal methods)
- H/o sensitivity to tocopherol-derivatives or medications used during bronchoscopy
- Inability to comply with the research protocol
We found this trial at
1
site
Nashville, Tennessee 37232
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