Neural Injury in Adolescents With Concussion
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Neurology, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 12 - 17 |
| Updated: | 7/26/2018 |
| Start Date: | April 11, 2017 |
| End Date: | June 1, 2018 |
This study utilizes multimodal brain imaging to obtain quantitative biomarkers of brain
injury and to improve understanding of the biological basis of brain pathology in adolescents
with concussion. Adolescents with a concussion will undergo neuroimaging and neuropsychology
assessments acutely and four months after injury.
injury and to improve understanding of the biological basis of brain pathology in adolescents
with concussion. Adolescents with a concussion will undergo neuroimaging and neuropsychology
assessments acutely and four months after injury.
Concussion is a highly prevalent condition in adolescence, but it remains a clinical
diagnosis that largely relies on subjective patient report with no reliable objective
biomarkers for diagnosis. Traditional clinical brain imaging has not been found useful for
concussion as the pathology is generally not visible on conventional acute MRI or CT. The
proposed study addresses this gap in concussion diagnosis and management by examining the
sensitivity of magnetoencephalography (MEG) for identifying areas of brain injury through
detection of abnormal neural activity (slowing) in adolescents with concussion compared to
healthy controls. Adolescents with a concussion will complete neuroimaging (MEG and MRI) and
neuropsychology assessments at two time points within ten days and then again 4 months
post-injury. Healthy controls will complete neuroimaging and neuropsychology assessments at a
single time point.
diagnosis that largely relies on subjective patient report with no reliable objective
biomarkers for diagnosis. Traditional clinical brain imaging has not been found useful for
concussion as the pathology is generally not visible on conventional acute MRI or CT. The
proposed study addresses this gap in concussion diagnosis and management by examining the
sensitivity of magnetoencephalography (MEG) for identifying areas of brain injury through
detection of abnormal neural activity (slowing) in adolescents with concussion compared to
healthy controls. Adolescents with a concussion will complete neuroimaging (MEG and MRI) and
neuropsychology assessments at two time points within ten days and then again 4 months
post-injury. Healthy controls will complete neuroimaging and neuropsychology assessments at a
single time point.
Inclusion Criteria:
- Diagnosis of concussion and within 2 weeks of injury (case subjects)
- No history of diagnosed concussion (control subjects)
Exclusion Criteria:
- Head injury within 1 year of recent concussion (case subjects)
- History of neurologic, psychiatric, developmental or learning disorders (all subjects)
We found this trial at
1
site
South 34th Street
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
215-590-1000
Phone: 215-590-1527
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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