Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery

Status:	Recruiting
Conditions:	Breast Cancer, Cancer, Chronic Pain, Chronic Pain, Chronic Pain, Depression
Therapuetic Areas:	Musculoskeletal, Oncology, Psychiatry / Psychology
Healthy:	No
Age Range:	21 - 80
Updated:	1/13/2019
Start Date:	January 3, 2018
End Date:	December 31, 2019
Contact:	Ban Leong Sng, FANZCA
Email:	sng.ban.leong@singhealth.com.sg
Phone:	+6563941081

Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery: A Prospective Cohort Study (Breast CAncer Surgery Postsurgical Pain)

Pre-existing pain and severe postoperative pain are predictors of persistent pain after
surgery, but a complete understanding on the development of persistent pain is still lacking.
The study aims to identify clinically relevant and genetic risk factors for persistent
postsurgical pain that can be reliably distinguished statistically.

The study will focus on: (i) risk factors representing biopsychosocial processes that
influence chronic pain, such as pain and psychological vulnerability; (ii) genetic factors
relating to mechanistic pathways to persistent pain generation. Patients will be recruited
from those undergoing breast cancer surgery at the mentioned site. Pain and anxiety
assessment will be conducted via visual analogue scoring, mechanical temporal summation
assessment and a series of questionnaires. After the surgery, all patients will be given
appropriate analgesia, and the pain score and analgesia usage will be recorded. Phone survey
will be conducted 4 and 6 months, respectively, after surgery to determine the outcomes.

Inclusion Criteria:

- Aged between 21 - 80 year old;

- Healthy and/or have systemic medical conditions as reviewed by anaesthetist for
surgery (ASA 1-3);

- Undergoing breast cancer surgery.

Exclusion Criteria:

- History of intravenous drug or opioid abuse;

- Current chronic daily treatment with corticosteroids (excluding inhaled steroids);

- Previous history of chronic pain syndrome;

- Obstetric patients.

We found this trial at

sites

KK Women's and Children's Hospital

Singapore, 22989

Principal Investigator: Ban Leong Sng, FANZCA

Phone: +6563941081

from

Singapore,