Effects of Antioxidants on Cardiovascular Risk Measures (Spice Study)



Status:Completed
Conditions:Cardiology, Psychiatric
Therapuetic Areas:Cardiology / Vascular Diseases, Psychiatry / Psychology
Healthy:No
Age Range:30 - 65
Updated:1/27/2018
Start Date:August 2009
End Date:September 2010

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Trial Summary
Trial Overview
Inclusion Criteria

Development of a Dynamic Model of Inflammation for Studying the Anti-inflammatory Effects of Culinary Spices in Human Participants

The purpose of this study is to assess whether feeding highly antioxidant spices of providing
these same antioxidants as capsules is able to affect cardiovascular risk measures. Because
this is a new area of research, the investigators will use many measures to assess this
question including blood markers, tests of blood vessel health, measures of blood pressure
responses, measures of clotting activity, and other inflammation measures.


Inclusion Criteria:

- Age 30-65

- BMI 25-40

- Non tobacco user

- Resting BP < 160/100

- Fasting Glucose < 126 mg/dL

Exclusion Criteria:

- Tobacco use

- Use of female hormones

- Breastfeeding or planning to become pregnant during the study

- Use of lipid-lowering or blood pressure medications

- Chronic Inflammatory Disease or osteoarthritis requiring regular use of medication

- Chronic use of any form of anti-inflammatory or anti-psychotic drugs

- Use of daily aspirin or supplements (except stable dose of calcium)

- History of heart attack or stroke, renal or hepatic disease, implanted medical
devices, gastrointestinal disease

- Allergy or intolerance to any study foods

- Injury to fingers or arms that would interfere with vascular and blood pressure
measurements

- Inability to comply with study protocol

- Allergy to adhesives or latex

- Aerobic exercise exceeding 2 hours per week
We found this trial at
1
site
Penn State GCRC
University Park, Pennsylvania 16802
?
mi
from
University Park, PA
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