Characterization and Epigenetics of Post-Partum Preeclampsia
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/27/2018 |
| Start Date: | February 1, 2017 |
| End Date: | February 1, 2021 |
This study will recruit women with post partum pre-eclampsia and match them to controls
without postpartum pre-eclampsia to identify an epigenetic signature that is specific to
women with post partum pre-eclampsia to help characterize the underlying pathophysiology of
post partum pre-eclampsia.
without postpartum pre-eclampsia to identify an epigenetic signature that is specific to
women with post partum pre-eclampsia to help characterize the underlying pathophysiology of
post partum pre-eclampsia.
Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies.
Approximately 10% of PEC patients will present with post-partum PEC without having developed
the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC)
is challenging because many women do not seek care until neurologic symptoms result from
severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC
are understudied and poorly understood. Identifying clinical risk factors and biomarkers of
PP-PEC would help to identify women at risk.
Approximately 10% of PEC patients will present with post-partum PEC without having developed
the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC)
is challenging because many women do not seek care until neurologic symptoms result from
severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC
are understudied and poorly understood. Identifying clinical risk factors and biomarkers of
PP-PEC would help to identify women at risk.
Inclusion Criteria:
- Post partum pre-eclampsia
Matching based on:
- maternal age (years +/-3)
- BMI (+/-5 points)
- Ethnicity
- Mode of delivery
- Gestational age at delivery (+/7 days)
- Smoking status
Exclusion Criteria:
- Intrapartum pre-eclampsia
We found this trial at
1
site
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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