Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome

Patients with short bowel syndrome (SBS) have a critical reduction of the gut mass/function
that is below the minimum needed to absorb nutrients and fluids required for adequate
homeostasis. There are limited data regarding the optimal choice for oral rehydration in the
setting of SBS that can maximize fluid absorption in the setting of diarrhea with limited
intestinal absorptive surface area. The investigators propose a preliminary open label single
center study assessing tolerability and palatability of enterade® ( an amino acid (AA) based
oral rehydrating solution (ORS)) and compare to baseline. Eligible patients with SBS will
participate in a 14-day trial monitoring and measuring tolerability and palatability of an
AA-ORS, enterade®, in addition to their regular diet.

Inclusion Criteria:

- Male and female patients with a diagnosis of short bowel syndrome (as defined by
surgical therapy for congenital or acquired gastrointestinal disease) between the ages
of 1-17

- Patients who are in intestinal continuity or with diverting ileostomy, jejunostomy

- Patients must be on a stable enteral nutrition regimen with oral rehydration fluids
that are taken orally.

- Stable GI medication regimen (e.g., loperamide, cholestyramine, small bowel bacterial
overgrowth (SBBO) regimen)

Exclusion Criteria:

- Patients receiving IV antibiotics within the previous 72h.

- Patients with a primary diagnosis of a motility disorder (e.g., chronic intestinal
pseudo-obstruction) or epithelial cell disorder (e.g., microvillus inclusion disease)

- Malnourished (as defined by Weight/Height Z-score (WHZ) <-2)