Early Detection of Lung Cancer

PRIMARY OBJECTIVES:

I. To provide screening for lung cancer in an underserved and high risk population for lung
cancer.

II. To collect clinical and demographic information and research bio specimens prospectively
on high risk individuals.

III. To analyze the association between suspected lung cancer risk factors and outcomes such
as pre-malignant lesions and diagnosis of lung cancer.

IV. To identify and validate biomarkers that are associated with lung cancer risk factors and
premalignant lesions.

V. To assess the association between patient characteristics and test results to the genetic
and histological characteristics of lung preinvasive lesions and cancers.

VI. To describe this high-risk cohort and to identify the patients eligible for future
clinical trials (e.g. chemoprevention).

OUTLINE:

Patients are followed up at 1, 2, 3, 4, and 5 years and undergo collection of sputum, nasal
epithelium, buccal epithelium, blood, and urine samples. Patients also undergo pulmonary
function tests, chest CT, and review of medical records.

Inclusion Criteria:

- Current smoker or former smoker, if former smoker participants must have quit smoking
within the past 15 years

- >= 30 pack year of smoking history

- Participant is uninsured

Exclusion Criteria:

- History of diagnosis/treatment of lung cancer in the past 2 years

- History of head/neck or esophageal cancer in the last 1 year

- Inability to provide informed consent