Oral Water Ingestion in Heart Transplant Patients

Status:	Active, not recruiting
Conditions:	High Blood Pressure (Hypertension), Cardiology
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	18 - Any
Updated:	8/12/2018
Start Date:	January 2006
End Date:	December 2019

Acute Hemodynamic Effects of Oral Water in a Stable Cardiac Transplant Population

In this study the investigators propose to assess the hemodynamic response to the ingestion
of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will
increase the systemic vascular resistance.

In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of
water. We will test the hypothesis that water ingestion will increase the systemic vascular
resistance. This study will occur in patients status post cardiac transplantation during
their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs
and plasma norepinephrine levels will be measured before and 30 min after the water
ingestion.

Inclusion Criteria:

- s/p cardiac transplantation scheduled for clinical right heart catheterization

- age > 18 years

Exclusion Criteria:

- significant tricuspid regurgitation

- inability to safely swallow 500 ml of water

- other major medical comorbidities such as advanced renal disease where water ingestion
may be harmful to patient

We found this trial at

sites

Vanderbilt University

2201 West End Ave
Nashville, Tennessee 37232

(615) 322-7311