Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/13/2018 |
| Start Date: | June 2016 |
| End Date: | August 28, 2018 |
MASH Study (Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients)
The study aim is to determine if periodic online cognitive exercises (Lumosity) improve
memory function in ruptured cerebral aneurysm patients with disabling baseline memory
deficits within the first 24 months after rupture. Half of the subjects will be randomized to
use Lumosity-designed online cognitive exercises and half will serve as an active control
group performing online crossword puzzles.
memory function in ruptured cerebral aneurysm patients with disabling baseline memory
deficits within the first 24 months after rupture. Half of the subjects will be randomized to
use Lumosity-designed online cognitive exercises and half will serve as an active control
group performing online crossword puzzles.
In this prospective randomized, control clinical trial subjects have a self-reported
disabling memory deficit within the first two years of their ruptured cerebral aneurysm.
Subjects will be recruited in the neurosurgery clinic setting, via email and phone screen,
through social media and phone screen, or during a monthly support group for the patient
population in question.
During the screening interview the inclusion and exclusion criteria are assessed and informed
consent is obtained if needed.
Those who qualify for the study will undergo a baseline assessment involving Checklist for
cognitive and emotional consequences following stroke (CLCE-24), Working memory
questionnaire, Activity of Daily living Questionnaire, and a Lumosity Administered
assessment.
After baseline assessments randomization will occur stratified according to duration since
SAH <12 or >12 months, to either a treatment group, which will include online access to
structure-oriented activities (Lumosity), or an active control group(online crossword
puzzles).
Subjects in the intervention group will undergo twenty training sessions over 10 weeks
involving cognitive games selected from Lumocity. Games will be customized using an automated
algorithm supplied by Lumosity, to determine performance in the various targeted skills,
which include: task switching, logical reasoning, quantitative reasoning, response
inhibition, numerical calculation, working memory, face-name recall, selective attention,
spatial recall, spatial orientations, planning, and divided attention. The recommended
duration of interaction is 2 hours per week for 10 weeks.
The control group uses a computerized crossword puzzle. the puzzle is offered in three
different puzzle sizes, levels of complexity, and font sizes. these puzzles do not provide
progressive challenge to the user by either increased speed, visual field size, number of
distractors, or degree of difficulty of target stimulus differentiation.
disabling memory deficit within the first two years of their ruptured cerebral aneurysm.
Subjects will be recruited in the neurosurgery clinic setting, via email and phone screen,
through social media and phone screen, or during a monthly support group for the patient
population in question.
During the screening interview the inclusion and exclusion criteria are assessed and informed
consent is obtained if needed.
Those who qualify for the study will undergo a baseline assessment involving Checklist for
cognitive and emotional consequences following stroke (CLCE-24), Working memory
questionnaire, Activity of Daily living Questionnaire, and a Lumosity Administered
assessment.
After baseline assessments randomization will occur stratified according to duration since
SAH <12 or >12 months, to either a treatment group, which will include online access to
structure-oriented activities (Lumosity), or an active control group(online crossword
puzzles).
Subjects in the intervention group will undergo twenty training sessions over 10 weeks
involving cognitive games selected from Lumocity. Games will be customized using an automated
algorithm supplied by Lumosity, to determine performance in the various targeted skills,
which include: task switching, logical reasoning, quantitative reasoning, response
inhibition, numerical calculation, working memory, face-name recall, selective attention,
spatial recall, spatial orientations, planning, and divided attention. The recommended
duration of interaction is 2 hours per week for 10 weeks.
The control group uses a computerized crossword puzzle. the puzzle is offered in three
different puzzle sizes, levels of complexity, and font sizes. these puzzles do not provide
progressive challenge to the user by either increased speed, visual field size, number of
distractors, or degree of difficulty of target stimulus differentiation.
Inclusion Criteria:
- Ruptured cerebral aneurysm-confirmed by study personnel within past year
- Age 18 and older
- Those with a modified Rankin 0 or 1
- Baseline memory problem affecting daily life
- Home computer or tablet with internet access
Exclusion Criteria:
- Unable to read or speak English
We found this trial at
1
site
1653 W. Congress Parkway
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Michael Chen, MD
Phone: 312-563-2817
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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