Dynamic Contrast Enhanced MRI (DCE-MRI) Diffusion Weighted MRI (DW-MRI) and Magnetic Resonance Spectroscopy (MRS) of Head and Neck Tumors

Magnetic resonance imaging (MRI) is a diagnostic study that makes pictures of organs of the
body using magnetic field and radio frequency pulses that can not be felt. Dynamic contrast
enhanced-magnetic resonance imaging (DCE-MRI) uses faster imaging and contrast material (a
substance used to make specific organs, blood vessels, or tumors easier to see) that is given
by vein. Diffusion weighted magnetic resonance imaging (DW-MRI) allows to measure the motion
of water around the cells in the tumor. Proton magnetic resonance spectroscopy (MRS) obtains
chemical information from the tumor. During MRS, signals are detected from the chemicals
(spectroscopy) naturally present in your tumor using radio waves. DCE-MRI, DW-MRI and MRS
give extra information which is not available with the regular MRI. The regular MRI only
shows pictures of the tumor while the DCE-MRI also gives information about the blood vessels
of the tumor. DW-MRI provides information related to the state of the tumor tissue with
regards to the quality or condition of cells present in it and MRS gives information about
the chemical makeup of the tumor.

The purpose of this study is to see whether DCE-MRI, DW-MRI and MRS done before treatment can
predict which patients will do well with either surgery or chemo-radiation therapy. This
study will also see if DCE-MRI, DW-MRI and MRS done early in treatment can tell if the
therapy is working.