Study to Evaluate the Pharmacokinetics of a New Tablet Formulation of CPI-444 in Fed and Fasted Healthy Male and Female Subjects

Inclusion Criteria:

1. Males or females, of any race, 18 to 65 years of age, inclusive, at Screening.

2. Body mass index between 18.5 and 32.0 kg/m2, inclusive, at Screening.

3. In good health.

4. Females will be nonpregnant and nonlactating, and females of childbearing potential
and males will agree to use contraception.

5. Able to comprehend and willing to sign an Informed Consent Form (ICF) and to abide by
the study restrictions.

Exclusion Criteria:

1. Significant history or clinical manifestation of any metabolic, allergic,
dermatological, hepatic, renal, hematological, pulmonary, cardiovascular,
gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder.

2. Subjects who have received any IMP in a clinical research study within 5 half-lives or
within 30 days prior to first dose.

3. Females of childbearing potential who are pregnant or lactating. Females of
non-childbearing potential are defined as permanently sterile or postmenopausal.
Postmenopausal status will be confirmed with a screening serum follicle-stimulating
hormone (FSH) level greater than 40 mIU/mL.

4. A history or evidence of clinically significant gastrointestinal disease, including
ulcers, gastro-esophageal reflux disease, or gastritis.

5. A history of alcoholism or drug/chemical abuse within 2 years prior to Period 1
Check-in.

6. Regular alcohol consumption of >21 units per week for males and >14 units for females.
One unit of alcohol equals 12 oz (360 mL) beer, 1½ oz (45 mL) liquor, or 5 oz (150 mL)
wine.

7. Positive urine drug screen (confirmed by repeat) at Screening (does not include
alcohol) or Check-in (does include alcohol).

8. Use of prescription or nonprescription drugs, including vitamins, herbal, and dietary
supplements (ie, St John's wort) within 7 days (or 14 days if the drug is a potential
enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of IMP.

9. Use of tobacco, smoking cessation products, or products containing nicotine
(including, but not limited to, cigarettes, e-cigarettes, pipes, cigars, chewing
tobacco, nicotine lozenges, or nicotine gum) within 6 months prior to Period 1
Check-in until Discharge from the CRU following the final dose.

10. Consumption of foods and beverages containing poppy seeds, grapefruit, or Seville
oranges will not be allowed from 7 days prior to Period 1 Check-in until Discharge
from the CRU following the final dose.

11. Consumption of caffeine-containing foods and beverages will not be allowed from 72
hours prior to Check-in until Discharge on Day 4 of each treatment period.

12. Poor peripheral venous access.

13. Evidence of renal impairment at Screening, as indicated by an estimated creatinine
clearance of less than 80 mL/min using the Cockcroft-Gault equation.

14. Screening chemistry laboratory values as follows: gamma-glutamyltransferase, aspartate
aminotransferase, and ALT >1.5 × institutional upper limit of normal (ULN), total
bilirubin >1.5 × institutional ULN.

15. A history of seizures (not including simple febrile seizures in childhood);

16. Multiple drug allergies or allergies to any of the components of CPI-444 tablets or
CPI 444 resinate capsules.

17. Known history of human immunodeficiency virus or active infection requiring therapy,
or positive tests for hepatitis B surface antigen or hepatitis C antibody.

18. Any vaccination against infectious diseases (ie, influenza, varicella) within 28 days
of first dose.

19. Donation or loss of greater than 400 mL of blood from 2 months prior to Screening,
donation of platelets from 6 weeks prior to Screening, or plasma from 2 weeks prior to
Screening through the Follow-up phone call.

20. Receipt of blood products within 2 months prior to Period 1 Check-in.

21. Subjects who, in the opinion of the Investigator (or designee), should not participate
in this study.