Statins in Cerebral Blood Flow and Neuronal Activity--A Pilot Study

A number of recent of recent studies suggests that statins, typically used to lower blood
cholesterol have an effect on the brain. Patients treated with statins may have increased
blood flow in the brain resulting in increased activity of the brain's neurons. The neuronal
system is linked to memory. Brain magnetic resonance imaging (MRI) with magnetic resonance
spectroscopy (MRS) and magnetic resonance perfusion (MRP) will be used to assess changes in
neuronal activity in patients receiving statins vs. patients not receiving statins.

This is a single-site non-randomized pilot study. The study will include twenty (20), healthy
consenting patients between the ages of 45 and 65 who are candidates for statin therapy as
determined by their cardiologist(s). Two imaging visits will be required, one magnetic
resonance imaging with Magnetic Resonance Spectroscopy and Magnetic Resonance Perfusion at
baseline and one magnetic resonance imaging with magnetic resonance Spectroscopy and Magnetic
Resonance Perfusion three months later as described.

Patients will have selected their course of clinical treatment prior to recruitment. Ten
patients will have elected to start statin therapy with Lipitor and ten patients will have
elected to initially lower their cholesterol levels with diet, independent of their
participation in the study.

Participants on the "statin arm" will receive a dose of 20 mg per day of Lipitor and will
receive a baseline brain Magnetic Resonance Imaging with Magnetic Resonance Spectroscopy and
Magnetic Resonance Perfusion prior to receiving Lipitor and follow-up brain Magnetic
Resonance Imaging with Magnetic Resonance Spectroscopy and Magnetic Resonance Perfusion three
months after beginning Lipitor.

Participants on the "diet arm" will receive a baseline brain magnetic resonance imaging with
Magnetic Resonance Spectroscopy and Magnetic Resonance Perfusion at the beginning of the
study and follow-up brain magnetic resonance imaging with magnetic resonance spectroscopy and
magnetic resonance perfusion three months later.

Inclusion Criteria:

1. Otherwise healthy adults, male or female

2. Age 45-65,

3. Prior to treatment with any statin at a moderate or high dose -

Exclusion Criteria:

1. Previous cerebral vascular accident,

2. Traumatic brain injury,

3. Subarachnoid hemorrhage,

4. Vascular dementia,

5. Alzheimer's Disease A

6. Any other known vascular pathologies of the brain.

7. Patients taking and/or receiving other known cerebrovascular enhancing
medication/herbs and/or treatment (examples: tPA, gingko, triple H therapy, stenting
procedures, etc.)

8. Previous neurosurgery or intracranial procedures.

9. Contraindication to MRI (pacemaker, neurostimulator, other surgical implants or metals
which would contraindicate MRI).