Radiation Biodosimetry in Patients Treated With Total Body Irradiation (TBI)

MSKCC patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will
have blood drawn and urine collected for use in the validation and refinement of new methods
for rapid high-throughput radiation biodosimetry. These blood and urine samples will be
collected before, and at defined times after TBI. Blood sampling will occur in the same
manner that it does during routine patient care during HSCT.

Inclusion Criteria:

- Patients greater than 4 years of age at Memorial Sloan-Kettering Cancer Center

- Must be undergoing hematopoietic stem cell transplantation (either autologous or
allogenic) in conjunction with a conditioning regimen that includes TBI (single or
multiple fraction)

- Functional central venous catheter

Exclusion Criteria:

- No subjects will be excluded from the proposed research study for demographic reasons.
Treatment with growth factors, such as keratinocyte growth factor (KGF), will not be
grounds for exclusion.

- Subjects who will receive radiation therapy within 5 days prior to TBI will be
excluded.

- Subjects who will receive systemic antineoplastic chemotherapy within 7 days prior to
TBI not have research bloods collected. Only urine will be collected from these
patients.

- Based on current knowledge, we will not a priori exclude patients based on disease
status (ie, patients in or out of remission will be included in this study), type of
disease(ie, chromosomal breakage syndromes), or previous therapies (unless exclusion
criteria is met).