Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus
Status: | Recruiting |
---|---|
Conditions: | Gastrointestinal |
Therapuetic Areas: | Gastroenterology |
Healthy: | No |
Age Range: | 18 - 85 |
Updated: | 3/9/2019 |
Start Date: | February 1, 2018 |
End Date: | November 1, 2019 |
Contact: | Baljit Kaur |
Email: | bkaur@kumc.edu |
Phone: | 913-588-3708 |
Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors to Everolimus
The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve
cognitive function by having less effect on brain blood flow.
cognitive function by having less effect on brain blood flow.
Inclusion Criteria:
- English speaking
- able to sign informed consent
- able to arrange transportation to and from study site
- without acute stroke, concussion or traumatic brain injury
- without acute medical issues at the time of participation
- after 12 weeks of the liver transplant surgery
Exclusion Criteria:
- are claustrophobic or have other contra-indication for magnetic resonance imaging
(MRI)
- have hearing or visual impairment
- are unable to read, write, speak or understand English
- have uncontrolled psychosis or seizure disorder or are currently using antipsychotics
or anti-epileptics
- within 12 weeks after transplant
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