Exploration and Determination of Genomic Markers Predictive of Uterine Atony
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/19/2018 |
| Start Date: | February 2, 2018 |
| End Date: | January 15, 2019 |
| Contact: | Jack Stecher, MD |
| Email: | jackstecher@sbcglobal.net |
| Phone: | 214-820-2126 |
The primary objective of this study is to determine whether there are markers in the tissue
of atonic uteri, and in the patients' plasma that would help identify patients likely to
suffer postpartum hemorrhage due to uterine atony. We also will attempt to identify the
cause(s) of uterine atony that might suggest mechanisms to prevent and manage it.
of atonic uteri, and in the patients' plasma that would help identify patients likely to
suffer postpartum hemorrhage due to uterine atony. We also will attempt to identify the
cause(s) of uterine atony that might suggest mechanisms to prevent and manage it.
Patient will be recruited from those admitted to our Labor and Delivery unit. Ten women will
be the control subjects, and these will be selected from patients who are admitted for
scheduled cesarean delivery. Ten women will be selected from women who develop uterine atony
either following cesarean delivery, or postpartum patients who delivered vaginally but
subsequently required surgical management of uterine atony (hysterectomy or uterine saving
surgery). From each patient a small amount of uterine muscle will be excised and placed in a
fixative, preservative transport medium. Ten cubic centimeters of blood will be drawn from
each patient to accompany the tissue. The tissue and blood will be processed and analyzed to
identify differences in the tissue and plasma of messenger RNA, micro RNA, long non-coding
RNA, and DNA methylation in normal and atonic uterine patients. Statistical analysis of these
markers will be performed to determine whether there are significant differences in their
expression. It is hoped that differences will be discovered that may be used diagnostically
to predict uterine atony, and differences that may suggest the etiology of uterine atony.
be the control subjects, and these will be selected from patients who are admitted for
scheduled cesarean delivery. Ten women will be selected from women who develop uterine atony
either following cesarean delivery, or postpartum patients who delivered vaginally but
subsequently required surgical management of uterine atony (hysterectomy or uterine saving
surgery). From each patient a small amount of uterine muscle will be excised and placed in a
fixative, preservative transport medium. Ten cubic centimeters of blood will be drawn from
each patient to accompany the tissue. The tissue and blood will be processed and analyzed to
identify differences in the tissue and plasma of messenger RNA, micro RNA, long non-coding
RNA, and DNA methylation in normal and atonic uterine patients. Statistical analysis of these
markers will be performed to determine whether there are significant differences in their
expression. It is hoped that differences will be discovered that may be used diagnostically
to predict uterine atony, and differences that may suggest the etiology of uterine atony.
Inclusion Criteria:
- 18 years of age or older
- female
- pregnancy over 23 weeks gestation
Exclusion Criteria:
- under 18 years of age
- prisoners
- non-female sex
- cannot provide informed consent
We found this trial at
1
site
Dallas, Texas 75246
Principal Investigator: Jack Stecher, MD
Phone: 214-820-2126
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