LABS-3 Psychosocial

Hypotheses

1. Patients undergoing bariatric surgery will experience significant decreases in the
rates of psychopathology, in particular depressive illness, and significant
improvements in quality of life, post-operatively.

2. Untreated psychopathology that persists well beyond the surgery (e.g. to one-year
follow-up) or that develops post-operatively will be associated with less weight loss
and decreased quality of life.

3. Untreated psychopathology at the time of bariatric surgery, including affective
disorders and substance abuse/alcohol abuse will be associated with increased
short-term (e.g. 90 day) complications (e.g. problems with plugging, vomiting, and
dehydration)

4. Syndromal/subsyndromal eating disorders prior to surgery including binge eating
disorder and night eating syndrome will be associated with eating disorder symptoms and
less weight loss at long-term follow-up.

Inclusion Criteria:

- Male and female patients who are at least 18 years of age and undergo bariatric
surgery by a LABS certified surgeon.

- Previous enrollment in LABS-1 and LABS-2.

- BMI at baseline of greater than or equal to 35.

Exclusion Criteria:

- Informed consent not obtained

- Type 1 Diabetes Mellitus

- Unlikely to comply with follow-up protocol (ie: geographically inaccessible for study
visits)

- Unable to communicate with local study staff