Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

Inclusion Criteria:

- Individuals with a personal and/or family history of lymphoma or lymphoproliferative
disease B-cell malignancies, or multiple myeloma referred for study participation, or
MSK patients referred from to the MSKCC outpatient clinics of the Lymphoma, Multiple
Myeloma, or Leukemia Services in the Department of Medicine in consultation for
treatment who are found on routine history or through a Family History Questionnaire
(FHQ) (Appendix A). Individuals who have relatives or members of successive
generations of the family affected with Hodgkin's disease, non-Hodgkin's lymphoma,
lymphoid leukemia, multiple myeloma other lymphoproliferative disease prostate or
pancreatic cancers, or other conditions suggesting hereditary cancer at the discretion
of the MSKCC Principal Investigator. Patients with lymphoma, associated with colon and
renal cancer will be eligible for DNA storage through this protocol. Family members or
probands with Hodgkin's disease who are women who received therapeutic irradiation for
Hodgkin's disease" or who developed secondary cancers after Hodgkin's disease are also
eligible for participation.

- The criteria for eligibility are broad because the ascertainment by the computerized
FHQ does not allow for resolution of different types of lymphoma or different types of
leukemia. Patient recall of this information is also imprecise. More accurate family
history information will be obtained upon contact of family members and diagnoses will
be verified by obtaining pathologic documentation. The spectrum of familial
lymphoproliferative syndromes (LPS) may include all types of lymphoma as well as
chronic lymphocytic leukemia. This is an additional reason to have a broad
eligibility. Subset analysis will be performed on specific types of lymphoid
neoplasms. DNA of patients with a family history of lymphoma who have consented to
protocol 93-102 ("Ascertainment of Peripheral Blood or Saliva Samples for Genetic
Epidemiology Studies of Familial Cancers") will also be eligible for inclusion in this
study.

- Family members of probands including patients, sisters, brothers, halfbrothers and
sisters, sons, daughters, grandparents, as well as aunts and uncles are also eligible.
An effort will be made to ascertain all living affected and unaffected living
relatives in the affected lineage. An emphasis will be on affected sibling pairs and
both parents, if alive.

- As this study involves research that presents no greater than minimal risk to children
(see Sec. 46.404 of Federal Regulations part 46), minors are also eligible for
participation. The assent of any minor should be obtained before the patient is
enrolled into this study, as well as the consent of the legal guardian.

Exclusion Criteria: