CRD-102 for Right Heart Failure in Patients With Left Ventricular Assist Devices

The study will be conducted over a 40 day time period inclusive of screening and follow up
time periods. Eligible subjects will receive oral CRD-102 for 14 days.

Inclusion Criteria:

Patients are enrolled only if they met the following criteria.

1. Males and females aged 18-85 years inclusive

2. Have received a LVAD (HeartWare HVAD, HeartMate II) at least 30 days prior to
screening.

3. Stable LVAD patients with evidence of ongoing right heart failure as evidenced by
raised right atrial pressure indicated by JVP >6cm OR measured right atrial pressure
≥12mmHg within the 3 months prior to or at Baseline OR dilated IVC on echocardiography
PLUS all of the following;

1. ongoing diuretic therapy;

2. echocardiography in the 3 months prior to or at Baseline showing at least mild
impairment in overall RV systolic function by visual assessment together with a
TAPSE < 14mm.

4. Able to give written informed consent and agree to adhere to all protocol
requirements.

5. All patients will be required to have an implanted cardiaoverter defibrillator. (ICD)

Exclusion Criteria:

1. Hemodynamically unstable patients.

2. Hypotension (MAP<60 or systolic BP <90 mmHg) at Screening or Baseline

3. Hypertension (MAP>95 or systolic BP >130 mmHg) at Screening or Baseline

4. Ventricular tachycardia or ventricular fibrillation in the past 30 days or poorly
controlled atrial fibrillation (ventricular rate >120 bpm)

5. Concurrent participation in another investigational device study or prior
participation in which a device was implanted and remains in place

6. Receipt of any investigational research agent within 30 days or 5 half-lives
(whichever is longer) prior to Baseline.

7. Current treatment with intravenous inotropes or levosimendan, or treatment within the
2 weeks prior to Screening

8. Significant renal (eGFR<25 ml/min/1.73 sq m) or hepatic (bilirubin >3mg/dL) impairment
or anemia (Hb <90g/dL) at Screening or Baseline.

9. Expected heart transplantation within the study period.

10. Pregnancy

11. History of allergic reaction to milrinone or any excipients in the study drug.