An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread
| Status: | Recruiting |
|---|---|
| Conditions: | Colorectal Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/16/2018 |
| Start Date: | February 14, 2018 |
| End Date: | August 18, 2022 |
| Contact: | Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, |
| Email: | Clinical.Trials@bms.com |
| Phone: | please email: |
An Open-Label Exploratory Phase 2/3 Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Metastatic Colorectal Cancer
This purpose of this study is to evaluate nivolumab (BMS-936558) in combination with standard
of care (SOC) chemotherapy with bevacizumab for the treatment of first-line metastatic
colorectal cancer (mCRC).
of care (SOC) chemotherapy with bevacizumab for the treatment of first-line metastatic
colorectal cancer (mCRC).
For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com
Inclusion Criteria:
- Histologically confirmed metastatic colorectal cancer, not amenable to curative
resection
- No prior chemotherapy for metastatic colorectal cancer
- ECOG Performance Status of 0-1
- Ability to provide adequate tissue sample
Exclusion Criteria:
- Patients with clinically relevant medical history, including autoimmune disease,
cardiovascular disease, hepatic disease or bleeding disorders
- Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or
any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint
pathways
- Any positive test result for hepatitis B virus or hepatitis C virus indicating
presence of virus
Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
42
sites
UAB Comprehensive Cancer Center One of the nation’s leading cancer research and treatment centers, the...
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185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-4000
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55 Fruit Street
Boston, Massachusetts 02215
Boston, Massachusetts 02215
Phone: 617-724-9347
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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1441 Eastlake Ave
Los Angeles, California 90033
Los Angeles, California 90033
(323) 865-3000
Phone: 323-865-3967
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
Nashville, Tennessee 37023
615-320-5090
Phone: 615-329-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Yale Cancer Center Yale Cancer Center combines a tradition of innovative cancer treatment and quality...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-220-9713
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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