Glycemic Index of Table Grape Varietals

The study aims to investigate the postprandial glycemic responses of healthy individuals when
consuming commercially available table grape varietals, compared to a standard amount of
glucose. The study also aims to evaluate a new grape varietal, compared to other common table
grapes, with regard to glycemic index and metabolic response related to inflammation.

Inclusion Criteria:

- Healthy men and women

- 21-75 years of age

- BMI range 20-35

Exclusion Criteria:

- adults unable to consent, individuals who are not yet adults (children), pregnant
women, and prisoners.

- BMI of >35 or morbid obesity.

- Diagnosed type 1 or 2 diabetes, fasting blood glucose of >125 mg/dl, or reported use
of medications or supplements known to affect glucose metabolism (insulin,
sulfonylureas, metformin, glucosidase inhibitors, thiazolidinedione, insulin
sensitizers, GLP-1 mimetics).

- Medications known to affect gastrointestinal motility (prokinetic agents such as
reglan).

- Renal, liver, pancreatic or cardiovascular disease, uncontrolled hypertension of >
160/90, inflammatory bowel disease, disorders of esophageal and gastrointestinal
motility, previous gastric resection or restriction procedures, autoimmune or
immunologic disorders, anemia, breastfeeding women

- Food allergy to grapes, or inability to tolerate gluten (celiac disease).

- Poor venous access.

- Smoking, illicit drug use, consuming >7 alcoholic drinks per week.

- Weight gain or loss of > 5 kg within the prior 6 months.

- Unwillingness to adhere to study protocol.