Improving Sleep Quality in Heart Failure
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 79 |
| Updated: | 2/2/2019 |
| Start Date: | November 1, 2017 |
| End Date: | January 25, 2019 |
Poor sleep quality is common in patients with heart failure. The limited available evidence
intimates that improving sleep quality in patients with heart failure may improve morbidity
and quality of life in this patient population. However, there is a paucity of evidence
assessing the use of effective pharmacologic therapies in heart failure. The
nonbenzodiazepine, GABA receptor agonist, zolpidem, has been found to have considerable
benefits over traditional benzodiazepines as a soporific medication. The investigators
hypothesize that zolpidem will safely improve sleep quality in patients with heart failure.
intimates that improving sleep quality in patients with heart failure may improve morbidity
and quality of life in this patient population. However, there is a paucity of evidence
assessing the use of effective pharmacologic therapies in heart failure. The
nonbenzodiazepine, GABA receptor agonist, zolpidem, has been found to have considerable
benefits over traditional benzodiazepines as a soporific medication. The investigators
hypothesize that zolpidem will safely improve sleep quality in patients with heart failure.
Inclusion Criteria:
- Age 21-79 years old
- HFrEF, EF ≤ 45% (by echocardiography)
- NYHA functional class I to III
- Able to give written consent
- On goal-directed medical therapy for HF, with stable dosing of HF medications for 2
weeks prior to enrollment
- No hospitalizations for HF within the past month
- Positive response to experiencing any of the following sleep-related symptoms at least
once a week:
- Difficulty falling asleep
- Waking up during the night and having difficulty getting back to sleep
- Waking up too early in the morning and being unable to get back to sleep.
Exclusion Criteria:
- Use of sedative-hypnotics, anxiolytic, or benzodiazepines within the previous 2 weeks
- Current treatment with other sedating medications such as opioids
- On therapy for pharmacological therapy for depression
- History of alcohol/drug dependence
- History of liver disease, HIV, or severe COPD
- On Thorazine
- Current use of ketoconazole
- Current use of tricyclic antidepressants
- Current use of macrolide antibiotics
- Current use of anticonvulsant medications
- Pregnancy. A urine pregnancy test will be performed to exclude pregnancy in potential
subjects.
We found this trial at
1
site
5501 Hopkins Bayview Circle
Baltimore, Maryland 21224
Baltimore, Maryland 21224
Phone: 410-550-4891
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