An Immuno-Therapy Study of Experimental Medication BMS-986205 Given With Nivolumab With or Without Chemotherapy Compared to Chemotherapy in Participants With Previously Untreated Stage IV or Recurrent Non-Small Cell Lung Cancer

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologically confirmed stage IV NSCLC per the 8th IASLC of squamous or nonsquamous
histology

- Locally advanced disease with recurrence after chemoradiation therapy (stage IIIB
disease, specifically refers to patients with no curative treatment options)

- No prior systemic anti-cancer therapy (including EGFR and ALK/ROS1 inhibitors) given
as primary therapy for advanced or metastatic disease

- Participants must have biomarker test results available for randomization

- ECOG Performance Status of ≤ 1

- Measurable disease by CT or MRI per RECIST 1.1 criteria

Exclusion Criteria:

- Participants with known sensitizing EGFR mutations or known ALK/ROS1 rearrangements

- Participants with interstitial lung disease that is symptomatic or may interfere with
the detection or management of suspected drug-related pulmonary toxicity

- Participants with an active, known or suspected autoimmune disease [Participants with
type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin
disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment,
or conditions not expected to recur in the absence of an external trigger are
permitted to enroll]

- Participants with untreated CNS metastases are excluded [Participants are eligible if
CNS metastases are adequately treated and participants are neurologically returned to
baseline (except for residual signs or symptoms related to the CNS treatment) for at
least 2 weeks prior to first treatment]

Other protocol defined inclusion/exclusion criteria could apply