Muscle Atrophy in Sepsis
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | December 2007 |
| End Date: | December 2009 |
| Contact: | Gregory A Schmidt, MD |
| Email: | gregory-a-schmidt@uiowa.edu |
| Phone: | 3193846746 |
Biochemical Pathways to Skeletal Muscle Atrophy in Human Sepsis
Severe sepsis will provoke signals leading to muscle atrophy and weakness. Electrical
stimulation will reduce the impact of sepsis.
stimulation will reduce the impact of sepsis.
Hypothesis 1: Severe sepsis will be associated with downregulation of anabolic signaling
molecules and genes, upregulation of catabolic signaling molecules and genes, and the
development of histologic and electrophysiologic abnormalities within skeletal muscle.
Hypothesis 2: Electrical stimulation will improve muscle strength in patients with sepsis.
Hypothesis 3: Electrical stimulation will be associated with upregulation of anabolic
signaling molecules and genes, downregulation of catabolic signaling molecules and genes,
and improvement of histologic and electrophysiologic parameters within skeletal muscle of
patients with sepsis.
Hypothesis 4: The ratio of catabolic:anabolic gene expression on Day 3 will be positively
correlated with the severity of clinical weakness on Day 7
molecules and genes, upregulation of catabolic signaling molecules and genes, and the
development of histologic and electrophysiologic abnormalities within skeletal muscle.
Hypothesis 2: Electrical stimulation will improve muscle strength in patients with sepsis.
Hypothesis 3: Electrical stimulation will be associated with upregulation of anabolic
signaling molecules and genes, downregulation of catabolic signaling molecules and genes,
and improvement of histologic and electrophysiologic parameters within skeletal muscle of
patients with sepsis.
Hypothesis 4: The ratio of catabolic:anabolic gene expression on Day 3 will be positively
correlated with the severity of clinical weakness on Day 7
Inclusion Criteria:
- Severe sepsis for < 72hr
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