Effect of Whey Protein Hydrolysate on Human Muscle Protein Synthesis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 20 - 35 |
| Updated: | 2/20/2019 |
| Start Date: | October 7, 2017 |
| End Date: | December 31, 2020 |
Muscle protein synthesis can be stimulated by ingestion of protein sources, such as whey,
casein or soy. Protein supplementation can be useful to restore protein turnover after
exercise but also to preserve skeletal muscle mass and function in aging adults. Ingestion of
large doses of essential amino acids (EAA) or certain protein supplements may be an effective
strategy to induce muscle protein synthesis. However, in many cases, it may not be practical
or feasible to consume a large volume of amino acids or protein required for an effective
response by muscle. Several evidences show how reduced strength and muscle mass, even in
early life, are predictors of early mortality which explicit the importance of developing
more effective methods to improve muscle quality. Therefore, identifying the better sources
of protein that have higher anabolic potency is of high significance.
The goal of this study is to determine the anabolic potency and efficacy of a new and novel
Whey Protein Hydrolysate mixture (WPH) on skeletal muscle protein synthesis in healthy young
subjects (age 20-35 yr). Previous studies on rats indicate WPH induces significant increases
in muscle protein synthesis compared with carbohydrates or whey-amino acid mixture. WPH
contains mostly peptides, which have physiological effects and could be absorbed more
rapidly. Preliminary data from preclinical study has also demonstrated that WPH can stimulate
muscle protein synthesis at lower doses compared with intact whey proteins. Thus, WPH could
be absorbed more rapidly and may maximally stimulate muscle protein synthesis. Although there
is substantial data on the individual effects of BCCA and intact protein such as whey, there
have been no clinical investigations that have explored the efficacy of WPH for stimulating
muscle protein synthesis in humans.
Therefore, the investigators propose that WPH will increase muscle protein synthesis.
They will compare the response of WHP to the response of WHEY when equal protein is provided
in both treatments.
10 healthy subjects will be recruited and will receive both WPH and WHEY supplementation in a
single blind crossover design. Muscle protein synthesis will be measured on both occasions.
This acute study will allow to determine whether low dose WPH supplementation will be an
effective nutritional treatment to stimulate muscle protein synthesis in young adults.
casein or soy. Protein supplementation can be useful to restore protein turnover after
exercise but also to preserve skeletal muscle mass and function in aging adults. Ingestion of
large doses of essential amino acids (EAA) or certain protein supplements may be an effective
strategy to induce muscle protein synthesis. However, in many cases, it may not be practical
or feasible to consume a large volume of amino acids or protein required for an effective
response by muscle. Several evidences show how reduced strength and muscle mass, even in
early life, are predictors of early mortality which explicit the importance of developing
more effective methods to improve muscle quality. Therefore, identifying the better sources
of protein that have higher anabolic potency is of high significance.
The goal of this study is to determine the anabolic potency and efficacy of a new and novel
Whey Protein Hydrolysate mixture (WPH) on skeletal muscle protein synthesis in healthy young
subjects (age 20-35 yr). Previous studies on rats indicate WPH induces significant increases
in muscle protein synthesis compared with carbohydrates or whey-amino acid mixture. WPH
contains mostly peptides, which have physiological effects and could be absorbed more
rapidly. Preliminary data from preclinical study has also demonstrated that WPH can stimulate
muscle protein synthesis at lower doses compared with intact whey proteins. Thus, WPH could
be absorbed more rapidly and may maximally stimulate muscle protein synthesis. Although there
is substantial data on the individual effects of BCCA and intact protein such as whey, there
have been no clinical investigations that have explored the efficacy of WPH for stimulating
muscle protein synthesis in humans.
Therefore, the investigators propose that WPH will increase muscle protein synthesis.
They will compare the response of WHP to the response of WHEY when equal protein is provided
in both treatments.
10 healthy subjects will be recruited and will receive both WPH and WHEY supplementation in a
single blind crossover design. Muscle protein synthesis will be measured on both occasions.
This acute study will allow to determine whether low dose WPH supplementation will be an
effective nutritional treatment to stimulate muscle protein synthesis in young adults.
The central hypothesis will be tested in 10 healthy young adults (20-35 yr). The subjects
will be studied in the post-absorptive state on two different days, during which they will
randomly assigned to drink a WPH or WHEY mixture.
Measures of muscle protein synthesis will be taken at baseline, one and three hours following
nutrient ingestion.
The expected outcome of the proposed work is the identification of a new nutritional strategy
for activating skeletal muscle protein synthesis. The findings of the proposed studies will
have a positive impact, because they will allow us to translate this information into
evidence-based clinical interventions to improve muscle size, strength and function and
improve recovery after conditions associated with muscle wasting.
will be studied in the post-absorptive state on two different days, during which they will
randomly assigned to drink a WPH or WHEY mixture.
Measures of muscle protein synthesis will be taken at baseline, one and three hours following
nutrient ingestion.
The expected outcome of the proposed work is the identification of a new nutritional strategy
for activating skeletal muscle protein synthesis. The findings of the proposed studies will
have a positive impact, because they will allow us to translate this information into
evidence-based clinical interventions to improve muscle size, strength and function and
improve recovery after conditions associated with muscle wasting.
Inclusion Criteria:
1. Men age 20-35 yrs
2. Stable body weight for at least 1 year
3. Able to provide written consent and understand the study requirements and procedures
Exclusion Criteria:
1. Exercise training
2. Significant heart, liver, kidney, blood, respiratory disease or thyroid issues
3. Peripheral vascular disease
4. Orthopedic injury
5. Diabetes mellitus or other untreated endocrine disease
6. Active cancer (all groups) and history of cancer
7. Acute infectious disease or history of chronic infections
8. Neurologic Injury or disease
9. Recent systemic treatment with anabolic steroids, or corticosteroids.
10. Alcohol or drug abuse
11. Tobacco use
12. Malnutrition
13. Obesity
14. Low hemoglobin levels
15. Food allergies
16. Taking dietary supplements
17. Chronic use of aspirin
We found this trial at
1
site
Click here to add this to my saved trials
