Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 12/19/2018 |
| Start Date: | March 13, 2017 |
| End Date: | May 1, 2020 |
| Contact: | Nicholas S Abend, MD |
| Email: | abend@chop.edu |
| Phone: | 215-590-1719 |
Electrographic seizures are common in critically ill patients leading to increased use of
resource-intense continuous EEG monitoring for seizure identification and management. When
identified, electrographic seizures are generally treated with anti-seizure medications, but
there are very limited data available regarding optimal treatment in terms of the efficacy or
safety of specific anti-seizure medications or overall management strategies.
This is a single-center prospective observational study. The investigators aim to: (1) track
critically ill patients undergoing clinically indicated EEG monitoring and seizure management
to identify risk factors for electrographic seizures, (2) create prediction models guiding
EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our
current management strategy in terms of safety.
resource-intense continuous EEG monitoring for seizure identification and management. When
identified, electrographic seizures are generally treated with anti-seizure medications, but
there are very limited data available regarding optimal treatment in terms of the efficacy or
safety of specific anti-seizure medications or overall management strategies.
This is a single-center prospective observational study. The investigators aim to: (1) track
critically ill patients undergoing clinically indicated EEG monitoring and seizure management
to identify risk factors for electrographic seizures, (2) create prediction models guiding
EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our
current management strategy in terms of safety.
Context: Electrographic seizures are common in critically ill patients leading to increased
use of resource-intense continuous EEG monitoring for seizure identification and management.
When identified, electrographic seizures are generally treated with anti-seizure medications,
but there are very limited data available regarding optimal treatment in terms of specific
medication selections or overall management strategies. The Children's Hospital of
Philadelphia (CHOP) has a formal ICU EEG Monitoring Pathway aiming to standardize EEG
monitoring and seizure management. This is a single-center prospective observational study of
patients undergoing clinically indicated EEG monitoring to identify risk factors for
electrographic seizures and create prediction models guiding limited EEG monitoring resources
to the patients at highest risk for seizures, and also to evaluate the current seizure
management strategy in terms of safety.
Objectives: The primary objective is to identify risk factors for electrographic seizures in
critically ill patients and use these risk factors to create and validate a seizure
prediction model. The secondary objective is to evaluate the safety of a targeted and timely
electrographic seizure identification and management strategy among critically ill patients
guided by a CHOP ICU EEG Monitoring Pathway.
Study Design: Single center observational study of consecutive patients undergoing clinically
indicated EEG monitoring.
Setting/Participants: Single-center study of critically ill children in the Pediatric ICU at
CHOP undergoing clinically indicated EEG monitoring and seizure management.
use of resource-intense continuous EEG monitoring for seizure identification and management.
When identified, electrographic seizures are generally treated with anti-seizure medications,
but there are very limited data available regarding optimal treatment in terms of specific
medication selections or overall management strategies. The Children's Hospital of
Philadelphia (CHOP) has a formal ICU EEG Monitoring Pathway aiming to standardize EEG
monitoring and seizure management. This is a single-center prospective observational study of
patients undergoing clinically indicated EEG monitoring to identify risk factors for
electrographic seizures and create prediction models guiding limited EEG monitoring resources
to the patients at highest risk for seizures, and also to evaluate the current seizure
management strategy in terms of safety.
Objectives: The primary objective is to identify risk factors for electrographic seizures in
critically ill patients and use these risk factors to create and validate a seizure
prediction model. The secondary objective is to evaluate the safety of a targeted and timely
electrographic seizure identification and management strategy among critically ill patients
guided by a CHOP ICU EEG Monitoring Pathway.
Study Design: Single center observational study of consecutive patients undergoing clinically
indicated EEG monitoring.
Setting/Participants: Single-center study of critically ill children in the Pediatric ICU at
CHOP undergoing clinically indicated EEG monitoring and seizure management.
Inclusion Criteria:
1. Care in the Children's Hospital of Philadelphia Pediatric ICU.
2. Clinically indicated continuous EEG monitoring.
3. Age > 1 month to 18 years.
Exclusion Criteria:
1. Admitted for Phase 2 (intracranial) EEG monitoring.
2. Intensivist expects to discontinue technological support in the next two days given
underlying medical or neurological problems.
We found this trial at
1
site
South 34th Street
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
215-590-1000
Phone: 215-590-1719
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