Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 10/13/2018 |
| Start Date: | July 1, 2017 |
| End Date: | December 2019 |
A growing body of work done over the past few decades has established that adipose tissue as
an active endocrine organ which secretes a wide range of metabolic and immunological factors
collectively called "adipokines (1)." Importantly, these secreted factors enter into the
circulation and have paracrine and autocrine actions, which profoundly impact systemic
metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone
production via ovariectomy (similar to menopause in humans) leads to increases in both in
adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy
than that from premenopausal animals. To date, no studies have investigated the effect of
menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific
changes occur with menopause may potentially lead to recommendations or therapeutics to
improve women's health post menopause.
an active endocrine organ which secretes a wide range of metabolic and immunological factors
collectively called "adipokines (1)." Importantly, these secreted factors enter into the
circulation and have paracrine and autocrine actions, which profoundly impact systemic
metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone
production via ovariectomy (similar to menopause in humans) leads to increases in both in
adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy
than that from premenopausal animals. To date, no studies have investigated the effect of
menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific
changes occur with menopause may potentially lead to recommendations or therapeutics to
improve women's health post menopause.
Subjects will just have to agree to having a small amount of adipose tissue being removed
during the bariatric surgery. The investigators will also collect a blood sample at that
time. There will be no other visits for the subject.
during the bariatric surgery. The investigators will also collect a blood sample at that
time. There will be no other visits for the subject.
Inclusion Criteria:
- Women who are premenopausal or who are postmenopausal and have been for at least one
year.
Males will be recruited to age match female subjects. All subject are already scheduled to
have bariatric surgery at the University of Missouri-Columbia Department of Surgery.
Exclusion Criteria:
- Women who are perimenopausal. Women who are on Hormone Replacement Therapy.
We found this trial at
1
site
Columbia, Missouri 65211
(573) 882-2121
Principal Investigator: Jill kanaley, PhD
Phone: 573-882-2519
University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...
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