FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)

This is a multicenter, open label, randomized study investigating two dose titration regimens
of CXA-10 in subjects at least 18 years of age with primary FSGS.

The study will be performed at approximately 25 study centers across the United States of
America (USA). The recruitment period is anticipated to be up to approximately 16 months.
Approximately 30 subjects will be randomized.

Study participation for each subject will last up to 5 months. The study will consist of a
screening period not to exceed 30 days (1 month), 90-day (3 month) treatment period, and an
approximate 28-day (1 month) follow-up period after the last dose of study medication.

Inclusion Criteria:

1. have a diagnosis of primary FSGS confirmed with biopsy.

2. eGFR or 24-hour creatinine clearance ≥ 40 mL/min/1.73 m2 at Screening.

3. The subject has a Up/c ratio ≥ 2 g protein/g creatinine based on a 24 hour urine
sample collected during Screening (one 24-hour collection between Day -30 and Day -8).

4. Unless there is an allergy or intolerance, subject must be on an ACEi and/or ARB
regimen for a minimum of 4 weeks prior to their screening Up/c assessment. The ACEi
and/or ARB regimen must be stable for a minimum of 2 weeks prior to screening Up/c
assessment (and there are no plans to change the ACEi/ARB regimen over the course of
the study).

5. If receiving simvastatin containing products: simvastatin (Zocor), Vytorin, or any
other combination therapy containing simvastatin, the simvastatin dose should not
exceed 20 mg/day.

6. Non-pregnant, non-lactating, female of childbearing potential who agrees to use a
reliable method of contraception or female is of non-childbearing potential defined as
surgically sterile (hysterectomy or bilateral tubal ligation) or post-menopausal.

Exclusion Criteria:

1. The subject has collapsing variant of FSGS on renal biopsy.

2. The subject has secondary FSGS.

3. The subject has diabetic nephropathy.

4. The subject has any other form of acquired (including biopsy proven obesity-induced
FSGS) or hereditary glomerular nephropathy.

5. The subject has a prolonged QTcF interval.

6. The subject is hypertensive.

7. The subject has a history of clinically significant cardiovascular events,
arrhythmias, recurrent fainting, palpitations, or family history of congenital
prolonged QT syndromes or sudden unexpected death due to a cardiac reason.

8. The subject has any known bleeding disorders or significant active peptic ulceration
in the opinion of the investigator that precludes enrollment into this study.

9. The subject has clinically significant anemia in the opinion of the investigator that
precludes enrollment into this study.

10. The subject has a history of any primary malignancy, including a history of melanoma
or suspicious undiagnosed skin lesions, with the exception of the following:

1. Basal cell or squamous cell carcinomas of the skin,

2. Cervical carcinoma in situ,

3. Other malignancies curatively treated and with no evidence of disease for at
least 5 years, or

4. Prostate cancer which is not currently or expected, during the study, to undergo
radiation therapy, chemotherapy, and/or surgical intervention, or to initiate
hormonal treatment.

11. The subject has a history of organ transplantation.

12. The subject has a history of HIV.

13. At the time of Screening (Visit 1), the subject has any co-existing disease or
condition.

14. Since the time of presentation of symptoms/diagnosis of FSGS: the subject has received
systemic (oral or parenteral) high-dose, long-term corticosteroid therapy (prednisone
or alternative glucocorticoid) to treat kidney disease

15. Subject has a history of immunosuppressant therapy (calcineurin inhibitors, rituximab,
or other non-steroid immunosuppressants).

16. The subject has a history of herbal or natural medication use (including fish oil)
within 2 weeks or 5 half-lives, whichever is longer, prior to Baseline

17. The subject is currently taking a drug that may affect the measurement of serum
creatinine (e.g. cimetidine, Bactrim, Pyridium).

18. The subject is currently taking a newly prescribed drug or new prescription for an
increased dose of an existing drug that is known to prolong the QTc interval and has
been associated with Torsades de pointes (a list is provided in Appendix H). Note:
Stable doses of these drugs are permitted (i.e., subject has received the same dose
and regimen for at least 30 days prior to Screening [Visit 1] with no anticipated
changes to the dose or regimen during the study).

19. The subject is currently taking endothelin receptor antagonists, dimethyl fumarate
(Tecfidera™), orlistat, fibrates (fenofibrate, bezafibrate, gemfibrozil and
ciprofibrate), niacin or lomatapide.

20. The subject has any of the following abnormal laboratories at Screening:

1. Serologic evidence of HIV, hepatitis B, or hepatitis C based on HIV antibody,
HBsAg, and HCV Ab,

2. Absolute lymphocyte counts below the lower limit of normal of the reference range

3. Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 3.0X
upper limit of normal (ULN), alkaline phosphatase > 2X ULN of liver origin, and
total bilirubin >2X ULN. If all LFTs are within normal limits (WNL) and total
bilirubin is elevated, examination of direct and indirect bilirubin may be
conducted to evaluate for Rotor's/Gilbert's Syndrome. Subjects with
Rotor's/Gilbert's Syndrome may be enrolled.

21. Female subject with a positive urine beta-human chorionic gonadotropin (β-hCG) test at
Screening (Visit 1) (all females) or Baseline (Visit 2) (females of childbearing
potential or with a history of bilateral tubal ligation in the absence of documented
menopause).

22. The subject has received a live attenuated vaccine within 6 weeks prior to Baseline
(Visit 2) or plans to receive a live attenuated vaccine during the study period.

23. The subject has a recent history (within one year prior to Screening [Visit 1]) of
abusing alcohol or illicit drugs (including marijuana) or history of extensive illicit
intravenous drug use.

24. Any other condition and/or situation that causes the Investigator to deem a subject
unsuitable for the study (e.g., due to expected study medication non-compliance,
inability to medically tolerate the study procedures, or a subject's unwillingness to
comply with study-related procedures).

25. The subject has known hypersensitivity to CXA-10, its metabolites, or formulation
excipients.

26. The subject has had treatment with any investigational drug or device within 30 days
or 5 half-lives (whichever is longer) prior to Screening (Visit 1) (this includes
investigational formulations of marketed products, inhaled and topical drugs), or
plans to participate in another investigational drug or device study at any time
during this study.