Behavioral Modification and Vesicare Versus Vesicare Alone for Urge Incontinence in Patients With Overactive Bladder

Overactive bladder symptoms are commonly treated with oral anticholinergic medications that
work by stopping muscles from tightening or behavioral modification. This study will help
determine if behavior modification (fluid regulation, pelvic exercises, timed voiding)
performed in conjunction wth oral Vesicare anticholinergic therapy, is more effective for
treating overactive bladder symptoms than oral Vesicare anticholinergic therapy alone.

Inclusion Criteria:

- Female patients > 18 years of age

- OAB symptoms for > 3 months

- Symptoms defined as greater than 3 episodes/week of an uncontrolled urge to void
causing incontinence.

- May or may not be accompanied by urinary frequency

- May be accompanied by stress urinary incontinence where stress incontinence does not
predominate

Exclusion Criteria:

- Male Patients

- Underlying cortical or spinal cord pathology including SCI, MS, or

- Parkinson's Disease

- Urinary retention with post-void residual > 150cc

- Current treatment or treatment within the last 3 months with anticholinergic
medications

- Patients not able to complete the questionaires or voiding diaries in English

- Pregnancy

- Active urinary tract infections

- Bladder Cancer or unevaluated hematuria

- Known diagnosis of narrow angle glaucoma

- Severe constipation

- History of reduced renal function (CrCl<30ml/min)

- History of liver disease

- Current treatment with cytochrome P450 inhibitor medications