Gene Expression in Hyperparathyroidism
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/18/2019 |
| Start Date: | November 7, 2012 |
| End Date: | November 2019 |
| Contact: | Nancy D. Perrier, MD |
| Phone: | 713-792-6940 |
Gene Expression in Hyperparathyroidism: Identifying Molecular Differences in MEN1 Patients Versus Young MEN1 Negative Patients
Objectives:
1. To better define the differences in molecular genetics of parathyroid tumors in patients
with MEN1, single gland parathyroid disease in patients less than 50 years old and
single gland disease in patients greater than 50 years old.
2. To better define the incidence of HRPT2 mutation in young patients with primary
hyperparathyroidism and determine whether routine testing in these patients is
indicated.
1. To better define the differences in molecular genetics of parathyroid tumors in patients
with MEN1, single gland parathyroid disease in patients less than 50 years old and
single gland disease in patients greater than 50 years old.
2. To better define the incidence of HRPT2 mutation in young patients with primary
hyperparathyroidism and determine whether routine testing in these patients is
indicated.
Patient charts will be reviewed to collect demographic data, pre-operative and post-operative
clinical and laboratory data, operative reports, and pathology reports. Archived
formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients
will be stained for parafibromin to evaluate for HRPT2 mutations.
clinical and laboratory data, operative reports, and pathology reports. Archived
formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients
will be stained for parafibromin to evaluate for HRPT2 mutations.
Inclusion Criteria:
1. All patients previously enrolled in parathyroid tissue banking under protocol
Lab08-0034.
2. For the subgroup designated for HRPT2 mutation testing:
Patients with primary hyperparathyroidism who are younger than 50 years of age and have
tested negative for MEN1, between January 1, 1980 and the present.
Exclusion Criteria:
We found this trial at
1
site
1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
Click here to add this to my saved trials
