Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride

Inclusion Criteria:

General and Dental Health

- Good general and dental health with (in the opinion of the investigator) no clinically
significant and relevant abnormalities of medical history or oral examination

- Have no current active caries or periodontal disease that may compromise the study or
the health of the subjects

- Residency: Currently living in the Indianapolis, Indiana area

Dentures:

- Currently wearing a removable mandibular partial denture with sufficient room in the
posterior buccal flange area to accommodate two enamel specimens (required dimensions
12 mm x 7 mm)

- Willing to have their denture modified to accommodate enamel test specimens and
willing and capable of wearing their removable mandibular partial dentures 24 hours
per day during the experimental periods

- All restorations in a good state of repair

- Salivary Flow: Have a salivary flow rate in the range of normal values (unstimulated
whole saliva flow rate ≥ 0.2 mL/minute; gum base stimulated whole saliva flow rate ≥
0.8 mL/minute)

Exclusion Criteria:

- Antibiotics: Use of antibiotics two weeks prior to a treatment visit or anticipated
use during the study treatment periods

- Study Scale Use: Subjects unable to measure product weights accurately using the
assigned study scale as determined by the study staff (as demonstrated on or before
Visit 4)

- A member of the site study staff who is directly working on the project or living in
that staff's household

- Any employee of any toothpaste manufacturer or their spouse or family member