A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Inclusion Criteria:

- Documented/confirmed first/second refractory/relapsed AML using World Health
Organization classification, except acute promyelocytic leukemia

- No more than 2 prior induction regimens (excluding prior HSCT) in their first line
treatment and one must have included cytarabine with an anthracycline (or
anthracenedione)

- Eastern Cooperative Oncology Group performance status of 0 to 1

- Adequate hepatic and renal function

- White blood cell (WBC) count at randomization less than or equal to ( per cubic millimeter (/mm^3)

Exclusion Criteria:

- First relapsed participants aged less than (<) 60 years with first CR duration greater
than (>) 1 year

- Participants with prior documented antecedent hematological disorder (AHD)

- AML secondary to any prior chemotherapy unrelated to leukemia

- Participants who are either refractory to or relapsed within 90 days of receiving a
regimen containing a cumulative dose of greater than or equal to (>/=) 18 g/m^2 of
cytarabine

- Participants who have received allogeneic HSCT within 90 days prior to randomization

- Participants who have received immunosuppressive therapy for graft versus host disease
within 2 weeks prior to randomization

- Prior treatment with an Murine Double Minute 2 (MDM2) antagonist

- Participants receiving any other investigational or commercial agents or therapies
administered with the intention to treat their malignancy within 30 days from first
receipt of study drug

- Participants with a history of other malignancy within 5 years prior to screening

- Participants who have any severe and/or uncontrolled medical conditions or other
conditions that could affect their participation in the study

- Participants with extramedullary AML with no evidence of systemic involvement

- Pregnant or breastfeeding participants