Red Light Treatment in Peripheral Artery Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 4/4/2019 |
| Start Date: | January 17, 2018 |
| End Date: | December 2023 |
| Contact: | Nicole L Lohr, MD,PHD |
| Email: | ntonn@mcw.edu |
| Phone: | 414-955-4261 |
Vasodilatory Effects of Light on Peripheral Artery Disease
Subjects with a known diagnosis of peripheral artery disease as measured by an abnormal ankle
brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above
the gastrocnemius muscle. Blood flow will be measured by infusion of ultrasound contrast and
subsequent acquisition of ultrasound images. 2 blood samples will be collected for
measurement of nitric oxide metabolites.
brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above
the gastrocnemius muscle. Blood flow will be measured by infusion of ultrasound contrast and
subsequent acquisition of ultrasound images. 2 blood samples will be collected for
measurement of nitric oxide metabolites.
Inclusion Criteria:
- Participants will be subjects between the ages of 18 and 85 who have been diagnosed
with peripheral artery disease. Men and women will be recruited for participation. All
ethnicities will be included in this study.
Diagnosis of peripheral artery disease is defined as an Ankle Brachial index of <0.9 or
greater than 1.1 either at rest or during treadmill exercise.
Exclusion Criteria:
- Exclusionary criteria include age under 18 years and over 85 years, those who are
unable to understand the consent process , those who cannot read or speak English,
active pregnancy, hypersensitivity to perflutren contrast agents, pulmonary
hypertension, active illicit drug use, untreated blood pressure over 160/95, sickle
cell disease, or a history of intracardiac shunt. Additional exclusion criteria
neurological diseases such as spinal stenosis, unspecified pain disorders, and any
uncontrolled medical conditions.
We found this trial at
1
site
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
Milwaukee, Wisconsin
(414) 955-8296
Phone: 414-955-4261
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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