Molecular Imaging of Breast Cancer With Breast PET/CT
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | April 2007 |
| End Date: | April 2012 |
| Contact: | Ramsey Badawi, PhD |
| Email: | ramsey.badawi@ucdmc.ucdavis.edu |
| Phone: | 916-734-7940 |
This study is a feasibility study to determine if a combined breast PET/CT scanner can image
malignant functional activity while determining anatomical structure in the same clinical
setting for patients with breast cancer. End-points of this study are whether women will
accept the imaging position and timing, and whether functional properties of breast cancer
can be imaged with this device. The secondary purpose of this study is to explore protocol
parameters with a view to optimizing imaging performance whilst minimizing patient
discomfort. Imaging results will be compared to histological samples to determine ground
truth.
PET is literally a molecular imaging modality. In monitoring the patient's response to a
specific chemotherapeutic regime, baseline and subsequent PET/CT scans can be used to
quantitatively determine the therapeutic effect of the regime, using the standard uptake
value (SUV), a common metric in PET imaging. The breast PET/CT system will facilitate
molecular imaging of breast cancer using a number of radiolabeled molecules, available both
commercially (18-FDG) and from the research environment.
Inclusion Criteria:
- Normal Adult Volunteers
- Female, at least 18 years of age
- Ability to lie motionless for up to 20 minutes
Patient Volunteers
- Female, at least 18 years of age
- Diagnostic findings from prior mammography highly suggestive of invasive breast
carcinoma (BI-RADS category 5)
- Not pregnant or breast-feeding
- Ability to lie motionless for up to 20 minutes
Exclusion Criteria:
- Normal Adult Volunteers
- Inability to understand the risks and benefits of the study
Patient Volunteers
- Recent breast biopsy
- Diagnostic findings from prior mammography highly suggestive of noninvasive ductal or
lobular carcinoma
- Uncontrolled diabetes
- Diabetic and blood sugar level > 200 mg/dL
- Positive urine pregnancy test or currently breast-feeding
- Inability to understand the risks and benefits of the study
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