Exercise, Fitness and Tumor Profiling in Breast Cancer Patients

Inclusion Criteria:

- Ages 21-80 years

- Female

- Histologically confirmed ER receptor positive (>1% staining), HER2 negative (FISH
ratio <1.8), untreated operable breast cancer

- Stage I to II disease

- Scheduled for surgical resection by any type of mastectomy or lumpectomy at MSK

- Tumor size ≥5mm, by preoperative imaging or physical examination

- Categorization into self-reported exercise history exposure classifications as
follows: (1) exercising: ≥120 minutes of vigorous-intensity exercise/wk for the past
12 months, and (2) sedentary (non-exercising): ≤ 30 minutes of moderate-intensity
exercise/week for the past months using the Harvard Health Professionals survey.(34)

- Ability to read and understand English

- Willing and able to comply with requirements of the protocol

Exclusion Criteria:

- Received any form of neoadjuvant treatment

- Presence of any other concurrent, actively treated malignancy

- Presence of metastatic disease

- If performing a CPET, any of the following contraindications:

- Acute myocardial infarction within 3-5 days of any planned study procedures;

- Unstable angina

- Uncontrolled arrhythmia causing symptoms or hemodynamic compromise

- Recurrent syncope

- Active endocarditis

- Acute myocarditis or pericarditis

- Symptomatic severe aortic stenosis

- Uncontrolled heart failure

- Acute pulmonary embolus or pulmonary infarction within 3 months of any planned
study procedures

- Thrombosis of lower extremities

- Suspected dissecting aneurysm

- Uncontrolled asthma

- Pulmonary edema

- Respiratory failure

- Acute non-cardiopulmonary disorders that may affect exercise performance or be
aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis).

- Mental impairment leading to inability to cooperate

- If performing a CPET, room air desaturation at rest ≤ 85%

- Any other condition or intercurrent illness that, in the opinion of the investigator,
makes the participant a poor candidate for the study.