Histological and Microbiological Evaluation of Late Occurring Nodules With Hyaluronic Acid Dermal Fillers

Inclusion Criteria:

- Have only received HA fillers (no limitation on the brand(s)/product(s) of HA filler
used; multiple product use is allowed).

- Present with an unresolved nodule (inflammatory or non-inflammatory) which was first
observed > 4 weeks and > 2 years after most recent HA filler treatment and is
determined to be greater than 3 millimeters (mm) in diameter by palpation

Exclusion Criteria:

- Have received non-HA fillers (e.g. polyacrylamide, calcium hydroxyapatite,
poly-L-lactic acid, polymethylmethacrylate, silicone, expanded
polytetrafluoroethylene, collagen) including mixes with HA fillers anywhere in the
face.

- Are currently enrolled in a dermal filler clinical trial or previously enrolled in a
dermal filler clinical trial with randomized treatment in which the type of dermal
filler is unknown (i.e. non-HA filler arm of study).

- Have history of keloid or hypertrophic scarring

- Have received intralesional intervention for the nodule (e.g. hyaluronidase,
corticosteroids, antibiotics, 5-fluorouracil).

- Are pregnant