Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN
| Status: | Completed |
|---|---|
| Conditions: | Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | December 2007 |
| End Date: | January 2011 |
Mannitol Bronchoprovocation Challenge Ancillary Study Protocol to Best Adjustment Strategy for Asthma Over Long Term
The overall hypotheses are: 1) an indirect airway challenge procedure using mannitol can
safely characterize asthma phenotypes, predict asthma control and exacerbations, predict
responses to interventions, and perform more specifically than a direct methacholine
challenge and; 2) PX27 pore function in whole blood correlates with measures of airway
hyperresponsiveness induced by methacholine and/or mannitol challenges
safely characterize asthma phenotypes, predict asthma control and exacerbations, predict
responses to interventions, and perform more specifically than a direct methacholine
challenge and; 2) PX27 pore function in whole blood correlates with measures of airway
hyperresponsiveness induced by methacholine and/or mannitol challenges
Inclusion Criteria:
- all subjects randomized to the BASALT protocol
Exclusion Criteria:
- positive urine pregnancy test
- requirement for more than two albuterol treatments for reversal of the methacholine
bronchoprovocation challenge procedure at visit 4 in the BASALT parent trial
We found this trial at
1
site
Madison, Wisconsin 53792
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