Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/3/2019 |
| Start Date: | October 16, 2017 |
| End Date: | December 31, 2019 |
| Contact: | Carissa Walter, MPH |
| Email: | cwalter2@kumc.edu |
| Phone: | 913-945-7450 |
The primary purpose of this project is to determine if acute monitoring of shunt patency via
ultrasound elastography measurements of splenic stiffness before and after TIPS placement
results in reduced morbidity and mortality from shunt failure.
ultrasound elastography measurements of splenic stiffness before and after TIPS placement
results in reduced morbidity and mortality from shunt failure.
Portal hypertension is a condition that is caused by various disorders of the liver,
including cirrhosis, hepatitis, portal vein thrombosis, or Budd-Chiari Disease. Portal
hypertension can lead to the accumulation of fluid in the abdomen, called ascites, or put
patients at risk for bleeding of the esophagus, stomach, and bowel. In certain patients,
portal hypertension is treated by placement of a Transjugular Intrahepatic Portosystemic
Shunt (TIPS).
Elastography is a newer exam which measures the consistency, or softness/stiffness, of
various organs in the body. It is performed with ultrasound by sliding a transducer across
the abdomen. Elastography is most commonly used to evaluate the liver, as disorders that
cause damage to the liver result in stiffer liver tissue. The spleen has also been shown to
get stiffer in the setting of portal hypertension.
including cirrhosis, hepatitis, portal vein thrombosis, or Budd-Chiari Disease. Portal
hypertension can lead to the accumulation of fluid in the abdomen, called ascites, or put
patients at risk for bleeding of the esophagus, stomach, and bowel. In certain patients,
portal hypertension is treated by placement of a Transjugular Intrahepatic Portosystemic
Shunt (TIPS).
Elastography is a newer exam which measures the consistency, or softness/stiffness, of
various organs in the body. It is performed with ultrasound by sliding a transducer across
the abdomen. Elastography is most commonly used to evaluate the liver, as disorders that
cause damage to the liver result in stiffer liver tissue. The spleen has also been shown to
get stiffer in the setting of portal hypertension.
Inclusion Criteria:
- All patients who undergo TIPS placement at the University of Kansas Medical Center
(KUMC) are eligible for participation in this study
Exclusion Criteria:
- Patients under 18 years of age
- Patients with prior splenectomy
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