Establishment of a Parathyroid Tissue Bank

Fresh residual tissue samples will be obtained during parathyroid and/or pancreas tumor
intervention (for pancreas tumor intervention in MEN1 patients with hyperparathyroidism and
pancreatic lesions).

In addition, outside paraffin tissue blocks or slides will be requested from patients
presenting to MDACC, or to participating family members who have had prior surgery outside of
MD Anderson.

Forty cubic centimeters (40 ccs) of whole blood will be obtained from individuals for
peripheral blood lymphocyte, plasma, and serum separation and analysis per event. Collections
may be made at any or all of the following timepoints: preoperatively, during intervention,
and/or at subsequent follow-up visits for up to fifteen years.

Inclusion Criteria:

1. Eligible participants will include patients presenting at MD Anderson Cancer who are
scheduled for surgical treatment of parathyroid disease and/or patients with MEN1,
and/or those presenting with hyperparathyroidism and/or pancreatic lesion, who are
scheduled for pancreas tumor intervention, as well as patients having had surgery and
who have had residual tissue stored under LAB02-518, LAB03-0320 or prior front door
consents, or who have had surgery at other centers and provide signed authorization to
obtain the tissue from the outside institution.

2. In addition, eligible participants may include family members of MD Anderson patients
who have been diagnosed with parathyroid disease and who have had surgery at other
centers, and who provide a signed authorization to obtain the tissue from outside
facilities AND/OR who begin care at MD Anderson and will be having intervention at MD
Anderson.

Exclusion Criteria: