Health Outcomes After Participating in Exercise (HOPE)
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Healthy Studies, Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology, Other |
| Healthy: | No |
| Age Range: | 55 - Any |
| Updated: | 3/1/2019 |
| Start Date: | February 20, 2018 |
| End Date: | December 31, 2021 |
Long-term Function and Health Effects of Intentional Weight Loss in Obese Elders
Aging is associated with significant declines in muscle mass, strength, and physical
performance, all of which lead to disability, loss of independence, and adverse clinical
outcomes. Obesity exacerbates these age-related declines in function and is associated with
poorer clinical outcomes and quality of life. Weight loss can also worsen age-related loss of
muscle mass and decrease bone mineral density. The overall goals of this study are to
determine if the short-term functional benefits of intentional weight loss are sustained
long-term, and to examine the long-term benefits and risks of weight loss.
performance, all of which lead to disability, loss of independence, and adverse clinical
outcomes. Obesity exacerbates these age-related declines in function and is associated with
poorer clinical outcomes and quality of life. Weight loss can also worsen age-related loss of
muscle mass and decrease bone mineral density. The overall goals of this study are to
determine if the short-term functional benefits of intentional weight loss are sustained
long-term, and to examine the long-term benefits and risks of weight loss.
Obesity exacerbates age-related declines in function and is associated with poorer clinical
outcomes and quality of life. Although clinical trials conducted study teams show that
diet-induced weight loss interventions in obese older adults, when combined with exercise,
improve body composition and physical and metabolic function in the short-term, the overall
safety and long-term benefits of intentional weight loss in older adults remain
controversial. Weight loss can also worsen age-related loss of muscle mass and decrease bone
mineral density. Because of these concerns, health care providers are reluctant to recommend
weight loss in obese older adults. The goal is to determine whether weight loss-induced
improvements in body composition and physical and metabolic function observed in short-term
clinical trials persist over time is critical to inform geriatric obesity treatment.
outcomes and quality of life. Although clinical trials conducted study teams show that
diet-induced weight loss interventions in obese older adults, when combined with exercise,
improve body composition and physical and metabolic function in the short-term, the overall
safety and long-term benefits of intentional weight loss in older adults remain
controversial. Weight loss can also worsen age-related loss of muscle mass and decrease bone
mineral density. Because of these concerns, health care providers are reluctant to recommend
weight loss in obese older adults. The goal is to determine whether weight loss-induced
improvements in body composition and physical and metabolic function observed in short-term
clinical trials persist over time is critical to inform geriatric obesity treatment.
Inclusion Criteria:
- All former participants from the five intervention trials who respond to our
recruitment strategies will be scheduled for clinic/home visits or a phone interview.
Exclusion Criteria:
- Participants with uncontrolled hypertension (≥180/100 mmHg) or resting heart rate <40
or >120 beats per minute
- Participants who report a recent (past 6 months) cardiac event or procedure or new or
recent worsening cardiac symptoms
- Participants who have had a hip fracture, hip or knee replacement, or spinal surgery
within the past 6 months
- Participants who cannot stand unassisted
- Participants with bilateral knee replacements
- Participants who have a history of brain aneurysm, cerebral bleeding in the past 6
months, or blood pressure ≥200/100 mmHg
- Participants who have had eye surgery (e.g., cataract surgery) within the past month
should have testing delayed (temporary exclusion)
- Surgery on hands or wrists in the past 3 months
- Pain or arthritis in hands that has gotten worse in the past 3 months
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