Comparison of Pharmacodynamic Effects of Tirofiban vs. Cangrelor in N-STEMI Patients Undergoing Percutaneous Coronary Intervention
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/15/2018 |
| Start Date: | August 23, 2017 |
| End Date: | May 29, 2019 |
| Contact: | Kevin Bliden, BS, MBA |
| Email: | kevin.bliden@inova.org |
| Phone: | 703-776-7702 |
Immediate potent inhibition of platelet function is critical for the prevention of
periprocedural ischemic event occurrences in high risk N-ST segment elevation myocardial
infarction (NSTEMI) in patients undergoing percutaneous coronary intervention (PCI).
Currently, dual antiplatelet therapy with aspirin and an oral P2Y12 receptor blocker (with
loading doses) is widely used for PCI. However, immediate, potent and reversible inhibition
of platelet aggregation is not possible even with the newer oral agents, prasugrel and
ticagrelor. Therefore, an intravenously administered GPIIb/IIIa receptor inhibitor
(tirofiban) or P2Y12 receptor blocker (cangrelor) with fast onset and offset of actions will
provide more desired antiplatelet effects in the setting of PCI. This study will measure and
compare the anti-platelet effects of Tirofiban and Cangrelor in patients presenting with
N-STEMI and undergoing PCI.
periprocedural ischemic event occurrences in high risk N-ST segment elevation myocardial
infarction (NSTEMI) in patients undergoing percutaneous coronary intervention (PCI).
Currently, dual antiplatelet therapy with aspirin and an oral P2Y12 receptor blocker (with
loading doses) is widely used for PCI. However, immediate, potent and reversible inhibition
of platelet aggregation is not possible even with the newer oral agents, prasugrel and
ticagrelor. Therefore, an intravenously administered GPIIb/IIIa receptor inhibitor
(tirofiban) or P2Y12 receptor blocker (cangrelor) with fast onset and offset of actions will
provide more desired antiplatelet effects in the setting of PCI. This study will measure and
compare the anti-platelet effects of Tirofiban and Cangrelor in patients presenting with
N-STEMI and undergoing PCI.
Inclusion Criteria:
1. NSTEMI meeting the following criteria:
1. Patients 18 years of age or older with one or more of the following symptoms:
- new ST-segment depression or transient elevation of at least 1 mm
- elevations in troponin I, troponin T, or creatine kinase MB levels above ULN
2. Eligible for ticagrelor, cangrelor, aspirin, UFH, and GP IIb/IIIa inhibitor treatment.
3. Admitted at cardiac catheterization laboratory hospital or associated facility.
4. Competent mental condition to provide informed consent.
Exclusion Criteria:
1. Unstable angina, STEMI
2. Cardiogenic shock
3. Refractory ventricular arrhythmias
4. New York Heart Association class IV congestive heart failure
5. Cardiac arrest within 1 week of study entry
6. History of hemorrhagic or ischemic stroke, TIA, sub-arachnoid hemorrhage or
intracranial neoplasm, arteriovenous malformation, or aneurysm
7. Fibrinolytic therapy within 48 hours of study entry
8. Active pathological bleeding or history of bleeding diathesis
9. Severe hepatic insufficiency
10. Current peptic ulceration
11. Increased bleeding risk, per investigator judgment
12. Known anemia (hematocrit<25%)/thrombocytopenia (platelet count < 100,000mm3)
13. Surgery within 4 weeks before study entry or planned surgery within 2 months after
study entry
14. Any P2Y12 receptor inhibitor or GP IIb/IIIa inhibitor within 7 days of study entry
15. Receiving warfarin or other coumadin derivatives or NOACs within the last 10 days with
an INR >1.5 secs or planned use during the hospitalization period
16. Contraindication to the use of ticagrelor and/or aspirin
17. Receiving or will receive oral anticoagulation or other oral antiplatelet therapy
(except aspirin) that cannot be safely discontinued within the next 3 months
18. Receiving daily NSAIDs or COX2 inhibitors that cannot be discontinued or anticipated
to require >2 weeks of daily NSAIDs or COX2 inhibitors during study
19. Investigational drug in last 30 days or presently enrolled in drug/device study
20. Women of childbearing potential (post-menopausal women can be enrolled if at least 1
year of amenorrhea or surgically sterile)
21. Condition associated with poor treatment compliance (e.g., alcoholism, mental illness,
or drug dependence)
22. Inability to provide written informed consent and to understand the full meaning of
the informed consent
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